N Pugh
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Explore the profile of N Pugh including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
342
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Recent Articles
1.
Nelson M, Noisette L, Pugh N, Gordeuk V, Hsu L, Wun T, et al.
Br J Haematol
. 2024 Jun;
205(2):653-663.
PMID: 38898714
Sickle cell disease (SCD) includes a group of heterogenous disorders that result in significant morbidities. HbSS is the most common type of SCD and HbSC is the second most common...
2.
Lopes-Pires M, Ahmed N, Vara D, Gibbins J, Pula G, Pugh N
Platelets
. 2020 Apr;
32(3):368-377.
PMID: 32248725
Vascular complications resulting from atherosclerosis development are a major cause of death. Reactive oxygen species (ROS) are produced by platelets during activation, and have been demonstrated to positively regulate platelet...
3.
Hadjistavropoulos H, Nugent M, Dirkse D, Pugh N
BMC Psychiatry
. 2017 Sep;
17(1):331.
PMID: 28899365
Background: Depression and anxiety are prevalent and under treated conditions that create enormous burden for the patient and the health system. Internet-delivered cognitive behavior therapy (ICBT) improves patient access to...
4.
Taylor K, Pugh N
Metallomics
. 2016 Jan;
8(2):144-55.
PMID: 26727074
Platelets are the primary cellular determinants of haemostasis and pathological thrombus formation leading to myocardial infarction and stroke. Following vascular injury or atherosclerotic plaque rupture, platelets are recruited to sites...
5.
Howes J, Pugh N, Knauper V, Farndale R
J Thromb Haemost
. 2015 Oct;
13(12):2253-9.
PMID: 26447617
Background: Atherothrombosis underlies acute coronary syndromes, including unstable angina and acute myocardial infarction. Within the unstable plaque, monocytes express collagenolytic matrix metalloproteinases (MMPs), including MMP-13, which degrades fibrous collagen. Following...
6.
Jarvis G, Bihan D, Hamaia S, Pugh N, Ghevaert C, Pearce A, et al.
J Thromb Haemost
. 2011 Nov;
10(2):268-77.
PMID: 22103309
Background: Collagen-induced platelet activation is a key step in the development of arterial thrombosis via its interaction with the receptors glycoprotein (GP)VI and integrin α(2) β(1) . Adhesion and degranulation-promoting...
7.
Sage S, Pugh N, Mason M, Harper A
J Thromb Haemost
. 2010 Dec;
9(3):540-51.
PMID: 21143372
Background: Most Ca(2+) signaling research in platelets has relied solely on monitoring the cytosolic Ca(2+) concentration ([Ca(2+)](cyt)). Changes in [Ca(2+)](cyt) constitute the net effect of Ca(2+) fluxes into the cytosol...
8.
Theobald P, Byrne C, Oldfield S, Dowson D, Benjamin M, Dent C, et al.
Proc Inst Mech Eng H
. 2007 Jul;
221(4):351-6.
PMID: 17605392
Fat pads are masses of encapsulated adipose tissue located throughout the human body. Whilst a number of studies describe these soft tissues anatomically little is known about their biomechanics, and...
9.
Theobald P, Bydder G, Dent C, Nokes L, Pugh N, Benjamin M
J Anat
. 2006 Jan;
208(1):91-7.
PMID: 16420382
Kager's fat pad is a mass of adipose tissue occupying Kager's triangle. By means of a combined magnetic resonance imaging, ultrasound, gross anatomical and histological study, we show that it...
10.
Theobald P, Benjamin M, Nokes L, Pugh N
Injury
. 2005 Oct;
36(11):1267-72.
PMID: 16214470
A region of avascularity mid-way along the length of the Achilles tendon has long been associated with rupture. Whilst it is agreed that this region is the location most common...