N O Concha
Overview
Explore the profile of N O Concha including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
405
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Recent Articles
1.
Head M, Ryan M, Lee D, Feng Y, Janson C, Concha N, et al.
J Comput Aided Mol Des
. 2002 Aug;
15(12):1105-17.
PMID: 12160093
Structure-based design of a combinatorial array was carried out in order to identify non-peptidic thiomethylketone inhibitors of caspases 3 and 8. Five compounds from the designed array were active against...
2.
Concha N, Abdel-Meguid S
Curr Med Chem
. 2002 Apr;
9(6):713-26.
PMID: 11945133
The intracellular cysteine proteinases grouped under the common name of caspases are important participants in the process of programmed cell death called apoptosis. Of the nearly fourteen mammalian members discovered...
3.
Lee D, Long S, Adams J, Chan G, Vaidya K, Francis T, et al.
J Biol Chem
. 2000 May;
275(21):16007-14.
PMID: 10821855
Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these proteases is whether selective inhibition of an effector caspase(s) will...
4.
Concha N, Janson C, Rowling P, Pearson S, Cheever C, Clarke B, et al.
Biochemistry
. 2000 Apr;
39(15):4288-98.
PMID: 10757977
Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there is a current lack...
5.
Concha N, Rasmussen B, Bush K, Herzberg O
Protein Sci
. 1998 Jan;
6(12):2671-6.
PMID: 9416622
The metallo-beta-lactamases require zinc or cadmium for hydrolyzing beta-lactam antibiotics and are inhibited by mercurial compounds. To data, there are no clinically useful inhibitors of this class of enzymes. The...
6.
Concha N, Rasmussen B, Bush K, Herzberg O
Structure
. 1996 Jul;
4(7):823-36.
PMID: 8805566
Background: The metallo-beta-lactamase from Bacteroides fragilis hydrolyzes a wide range of beta-lactam antibiotics, and is not clinically susceptible to any known beta-lactamase inhibitors. B. fragilis is associated with post-surgery hospital...
7.
Swairjo M, Concha N, Kaetzel M, Dedman J, Seaton B
Nat Struct Biol
. 1995 Nov;
2(11):968-74.
PMID: 7583670
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes...
8.
Concha N, Head J, Kaetzel M, Dedman J, Seaton B
Science
. 1993 Sep;
261(5126):1321-4.
PMID: 8362244
Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V...
9.
Concha N, Head J, Kaetzel M, Dedman J, Seaton B
FEBS Lett
. 1992 Dec;
314(2):159-62.
PMID: 1459245
The quaternary structure of annexin V, a calcium-dependent phospholipid binding protein, was investigated by chemical cross-linking. Calcium was found to induce the formation of trimers, hexamers, and higher aggregates only...