N M Allewell
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Explore the profile of N M Allewell including associated specialties, affiliations and a list of published articles.
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62
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619
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Recent Articles
1.
2.
Ha Y, Theil E, Allewell N
Acta Crystallogr D Biol Crystallogr
. 2004 Aug;
53(Pt 5):513-23.
PMID: 15299881
The ferritins are a multigene family of proteins that concentrate and store iron in all prokaryotic and eukaryotic cells. 24 monomeric subunits which fold as four-helix bundles assemble to form...
3.
Mavinakere M, Morizono H, Shi D, Allewell N, Tuchman M
J Inherit Metab Dis
. 2002 Jan;
24(6):614-22.
PMID: 11768581
Ornithine carbamoyltransferase (OCT) deficiency is now frequently found in adults with hyperammonaemia affected by mutations that cause partial deficiency of this urea cycle enzyme. One of these mutations (R40H) has...
4.
Shi D, Morizono H, Yu X, Tong L, Allewell N, Tuchman M
Acta Crystallogr D Biol Crystallogr
. 2001 Apr;
57(Pt 5):719-21.
PMID: 11320316
Wild-type human ornithine transcarbamylase (OTCase) and two mutants (R277Q and R277W) that cause 'late-onset' hyperammonemia were crystallized and a preliminary structure determination was carried out. The unliganded wild-type enzyme crystallizes...
5.
Shi D, Morizono H, Yu X, Tong L, Allewell N, Tuchman M
Biochem J
. 2001 Mar;
354(Pt 3):501-9.
PMID: 11237854
Two crystal structures of human ornithine transcarbamylase (OTCase) complexed with the substrate carbamoyl phosphate (CP) have been solved. One structure, whose crystals were prepared by substituting N-phosphonacetyl-L-ornithine (PALO) liganded crystals...
6.
Shi D, Morizono H, Aoyagi M, Tuchman M, Allewell N
Proteins
. 2000 May;
39(4):271-7.
PMID: 10813810
The crystal structure of human ornithine transcarbamylase (OTCase) complexed with carbamoyl phosphate (CP) and L-norvaline (NOR) has been determined to 1.9-A resolution. There are significant differences in the interactions of...
7.
Ha Y, Shi D, Small G, Theil E, Allewell N
J Biol Inorg Chem
. 1999 Aug;
4(3):243-56.
PMID: 10439069
Ferritins concentrate and store iron as a mineral in all bacterial, plant, and animal cells. The two ferritin subunit types, H or M (fast) and L (slow), differ in rates...
8.
Licata V, Burz D, Moerke N, Allewell N
Biochemistry
. 1998 Dec;
37(50):17381-5.
PMID: 9860853
Global conformational transitions are of central functional importance for many enzymes and binding proteins. It is not known, however, how much variability can exist in such structural-functional linkages. We have...
9.
Shi D, Morizono H, Ha Y, Aoyagi M, Tuchman M, Allewell N
J Biol Chem
. 1998 Dec;
273(51):34247-54.
PMID: 9852088
The crystal structure of human ornithine transcarbamoylase complexed with the bisubstrate analog N-phosphonacetyl-L-ornithine has been solved at 1.85-A resolution by molecular replacement. Deleterious mutations produce clinical hyperammonia that, if untreated,...
10.
Ha Y, Allewell N
Proteins
. 1998 Nov;
33(3):430-43.
PMID: 9829701
Tyr 165 in the catalytic subunit of Escherichia coli aspartate transcarbamoylase (ATCase, EC 2.1.3.2) forms an intersubunit hydrogen bond in the T state with Glu 239 in the 240s loop...