N Lassam
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Explore the profile of N Lassam including associated specialties, affiliations and a list of published articles.
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16
Citations
494
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Recent Articles
1.
Hogg D, Liu L, Lassam N
Methods Mol Med
. 2012 Feb;
61:109-22.
PMID: 22323255
The first description of familial melanoma in the English literature appeared in 1820, when Norris (1) reported: It is remarkable that this gentleman's father, about thirty years ago, died of...
2.
Leung I, Lassam N
J Biol Chem
. 2000 Oct;
276(3):1961-7.
PMID: 11053428
We have demonstrated previously that Cdc42 induced MLK-3 homodimerization leads to both autophosphorylation and activation of MLK-3 and postulated that autophosphorylation is an intermediate step of MLK-3 activation following its...
3.
Yakobson E, Shemesh P, Azizi E, Winkler E, Lassam N, Hogg D, et al.
Eur J Hum Genet
. 2000 Aug;
8(8):590-6.
PMID: 10951521
Germline mutations in the p16 (CDKN2A) tumour suppressor gene have been linked to inherited predisposition to malignant melanoma (MM). Variable frequencies of p16 germline mutations were reported in different collections...
4.
Nord B, Platz A, Smoczynski K, Kytola S, Robertson G, Calender A, et al.
Int J Cancer
. 2000 Aug;
87(4):463-7.
PMID: 10918183
Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome associated primarily with endocrine tumors of the parathyroids, enteropancreas and anterior pituitary. However, tumors of mesenchymal origin such...
5.
Shennan M, Badin A, Walsh S, Summers A, From L, McKenzie M, et al.
Oncogene
. 2000 Apr;
19(14):1849-52.
PMID: 10777219
Germline mutations in genes encoding several components of the retinoblastoma pathway have been linked with inherited predisposition to melanoma. Most commonly, such mutations involve CDKN2A, a cyclin-dependent kinase inhibitor of...
6.
Hehner S, Hofmann T, Ushmorov A, Dienz O, Lassam N, Scheidereit C, et al.
Mol Cell Biol
. 2000 Mar;
20(7):2556-68.
PMID: 10713178
The phosphorylation of IkappaB by the multiprotein IkappaB kinase complex (IKC) precedes the activation of transcription factor NF-kappaB, a key regulator of the inflammatory response. Here we identified the mixed-lineage...
7.
Dilworth D, Liu L, Stewart A, Berenson J, Lassam N, Hogg D
Blood
. 2000 Feb;
95(5):1869-71.
PMID: 10688850
Germline mutations of the CDKN2A (p16(INK4A)) tumor suppressor gene predispose patients to melanoma and pancreatic carcinoma. In contrast, mutations of the murine CDKN2A gene predispose BALB/c mice to pristane-induced plasmacytoma....
8.
Liu L, Dilworth D, Gao L, Monzon J, Summers A, Lassam N, et al.
Nat Genet
. 1999 Jan;
21(1):128-32.
PMID: 9916806
Approximately 8-12% of melanoma is inherited in an autosomal dominant fashion with variable penetrance. A chromosome 9p21 locus has been linked to this disease in 50-80% of affected families. CDKN2A...
9.
Leung I, Lassam N
J Biol Chem
. 1998 Nov;
273(49):32408-15.
PMID: 9829970
Mixed lineage kinase-3 (MLK-3) is a mitogen-activated kinase kinase kinase that mediates stress-activating protein kinase (SAPK)/c-Jun NH2-terminal kinase activation. MLK-3 and other MLK family kinases are characterized by the presence...
10.
Kiefer F, Tibbles L, Lassam N, Zanke B, Iscove N, Woodgett J
Biochem Soc Trans
. 1997 May;
25(2):491-8.
PMID: 9191142
No abstract available.