N J Clegg
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Explore the profile of N J Clegg including associated specialties, affiliations and a list of published articles.
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20
Citations
398
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Recent Articles
1.
Keaton A, Solomon B, Kauvar E, El-Jaick K, Gropman A, Zafer Y, et al.
Mol Syndromol
. 2011 Nov;
1(5):211-222.
PMID: 22125506
Holoprosencephaly (HPE), which results from failed or incomplete midline forebrain division early in gestation, is the most common forebrain malformation. The etiology of HPE is complex and multifactorial. To date,...
2.
Hahn J, Barnes P, Clegg N, Stashinko E
AJNR Am J Neuroradiol
. 2010 May;
31(9):1596-601.
PMID: 20488907
HPE is a congenital brain malformation characterized by failure of the prosencephalon to divide into 2 hemispheres. We have identified 7 patients who have a mild subtype of HPE in...
3.
Lacbawan F, Solomon B, Roessler E, El-Jaick K, Domene S, Velez J, et al.
J Med Genet
. 2009 Apr;
46(6):389-98.
PMID: 19346217
Background: Holoprosencephaly (HPE) is the most common structural malformation of the human forebrain. There are several important HPE mutational target genes, including the transcription factor SIX3, which encodes an early...
4.
Barkovich A, Simon E, Glenn O, Clegg N, Kinsman S, Delgado M, et al.
Neurology
. 2002 Dec;
59(12):1968-71.
PMID: 12499493
In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including...
5.
Lewis A, Simon E, Barkovich A, Clegg N, Delgado M, Levey E, et al.
Neurology
. 2002 Dec;
59(12):1860-5.
PMID: 12499474
Background: The middle interhemispheric variant (MIH) is a subtype of holoprosencephaly (HPE) in which the posterior frontal and parietal areas lack midline separation, whereas more polar areas of the cerebrum...
6.
Plawner L, Delgado M, Miller V, Levey E, Kinsman S, Barkovich A, et al.
Neurology
. 2002 Oct;
59(7):1058-66.
PMID: 12370462
Background: Despite advances in neuroimaging and molecular genetics of holoprosencephaly (HPE), the clinical spectrum of HPE has remained inadequately described. Objective: To better characterize the clinical features of HPE and...
7.
Weatherman R, Chang C, Clegg N, Carroll D, Day R, Baxter J, et al.
Mol Endocrinol
. 2002 Mar;
16(3):487-96.
PMID: 11875107
Some aspects of ligand-regulated transcription activation by the estrogen receptor (ER) are associated with the estrogen-dependent formation of a hydrophobic cleft on the receptor surface. At least in vitro, this...
8.
Simon E, Hevner R, Pinter J, Clegg N, Delgado M, Kinsman S, et al.
Neuroradiology
. 2001 Oct;
43(9):787-91.
PMID: 11594433
The dorsal cyst is poorly understood, although it is commonly encountered in holoprosencephaly. We endeavor to establish the role of diencephalic malformations in the formation of the dorsal cyst and...
9.
Weatherman R, Clegg N, Scanlan T
Chem Biol
. 2001 May;
8(5):427-36.
PMID: 11358690
Background: The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen are triphenylethylene derivatives that affect transcriptional regulation by the estrogen receptors (ERalpha and ERbeta) but show different effects in different...
10.
Clegg N, Findley S, Mahowald A, Ruohola-Baker H
Dev Genes Evol
. 2001 Mar;
211(1):44-8.
PMID: 11277405
The factors that determine intracellular polarity are largely unknown. In Drosophila oocytes one of the earliest polar events is the positioning of the microtubule-organizing center (MTOC). Here we present data...