N J Caplen
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Explore the profile of N J Caplen including associated specialties, affiliations and a list of published articles.
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22
Citations
757
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Recent Articles
1.
Martin S, Wu Z, Gehlhaus K, Jones T, Zhang Y, Guha R, et al.
Curr Cancer Drug Targets
. 2011 Aug;
11(8):976-86.
PMID: 21834757
In an effort to develop strategies that improve the efficacy of existing anticancer agents, we have conducted a siRNA-based RNAi screen to identify genes that, when targeted by siRNA, improve...
2.
Calcagno A, Fostel J, To K, Salcido C, Martin S, Chewning K, et al.
Br J Cancer
. 2008 Apr;
98(9):1515-24.
PMID: 18382425
Understanding the mechanisms of multidrug resistance (MDR) could improve clinical drug efficacy. Multidrug resistance is associated with ATP binding cassette (ABC) transporters, but the factors that regulate their expression at...
3.
Caplen N
Gene Ther
. 2004 Aug;
11(16):1241-8.
PMID: 15292914
The control and maintenance of gene expression is critical for cell development and differentiation. Over the last 2 years, our understanding of the role of RNA as a regulator of...
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Caplen N, Parrish S, Imani F, Fire A, Morgan R
Proc Natl Acad Sci U S A
. 2001 Aug;
98(17):9742-7.
PMID: 11481446
Short interfering RNAs (siRNAs) are double-stranded RNAs of approximately 21-25 nucleotides that have been shown to function as key intermediaries in triggering sequence-specific RNA degradation during posttranscriptional gene silencing in...
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Caplen N, Fleenor J, Fire A, Morgan R
Gene
. 2000 Jul;
252(1-2):95-105.
PMID: 10903441
RNA interference (RNAi) is a form of post-transcriptional gene silencing that has been described in a number of plant, nematode, protozoan, and invertebrate species. RNAi is characterized by a number...
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Caplen N, Higginbotham J, Scheel J, Vahanian N, Yoshida Y, Hamada H, et al.
Gene Ther
. 1999 Aug;
6(3):454-9.
PMID: 10435096
Several hybrid viral gene transfer systems have been described that exploit the favorable features of the two parent viral species. We have developed a hybrid adeno-retroviral vector system to generate...
10.