N H Ruddle
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Explore the profile of N H Ruddle including associated specialties, affiliations and a list of published articles.
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Articles
109
Citations
3292
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Recent Articles
1.
Ruddle N
Immunol Today
. 2014 Oct;
7(1):8-9.
PMID: 25291416
The etiological agent of the acquired immunodeficiency syndrome (AIDS), lymphadenopathy-associated virus/human T-lymphotropic virus III (LAV/HTLV-III), infects the OKT4(+) subset of T cells and causes their death. In this article Nancy...
2.
Ruddle N
Immunol Today
. 2014 Oct;
6(5):156-9.
PMID: 25289782
Lymphotoxin, (LT), a ymphokine released by activated lymphocytes, kills bystander cells such as fibroblasts and lymphocytes. Its production by mouse T cells is antigen-specific and restricted by MHC genes. It...
3.
Li C, Horowitz M, Ruddle N
Sci China C Life Sci
. 2008 Aug;
42(1):8-16.
PMID: 18726492
Neurofibroma cell lines derived from mice transgenic for HTLV-I LTR tax express high levels of HTLV-I tax mRNA and protein and exhibit a transformed phenotype. A retrovirus vector carrying HTLV-I...
4.
Nasr I, Reel M, Oberbarnscheidt M, Mounzer R, Baddoura F, Ruddle N, et al.
Am J Transplant
. 2007 Mar;
7(5):1071-9.
PMID: 17359505
Tertiary lymphoid tissues are lymph node-like cell aggregates that arise at sites of chronic inflammation. They have been observed in transplanted organs undergoing chronic rejection, but it is not known...
5.
Hemmerich S, Bistrup A, Singer M, van Zante A, Lee J, Tsay D, et al.
Immunity
. 2001 Aug;
15(2):237-47.
PMID: 11520459
Lymphocytes home to lymph nodes, using L-selectin to bind specific ligands on high endothelial venules (HEV). In vitro studies implicate GlcNAc-6-sulfate as an essential posttranslational modification for ligand activity. Here,...
6.
Dong C, Juedes A, Temann U, Shresta S, Allison J, Ruddle N, et al.
Nature
. 2001 May;
409(6816):97-101.
PMID: 11343121
T-lymphocyte activation and immune function are regulated by co-stimulatory molecules. CD28, a receptor for B7 gene products, has a chief role in initiating T-cell immune responses. CTLA4, which binds B7...
7.
Spahn T, Fontana A, Faria A, Slavin A, Eugster H, Zhang X, et al.
Eur J Immunol
. 2001 Apr;
31(4):1278-87.
PMID: 11298355
Systemic hyporesponsiveness occurs following oral administration of antigen (oral tolerance) and involves the uptake and processing of antigen by the gut-associated lymphoid tissue (GALT), which includes Peyer's patches (PP) lamina...
8.
Juedes A, Ruddle N
J Immunol
. 2001 Apr;
166(8):5168-75.
PMID: 11290800
During experimental autoimmune encephalomyelitis (EAE), autoreactive Th1 T cells invade the CNS. Before performing their effector functions in the target organ, T cells must recognize Ag presented by CNS APCs....
9.
Goluszko E, Hjelmstrom P, Deng C, Poussin M, Ruddle N, Christadoss P
J Neuroimmunol
. 2001 Jan;
113(1):109-18.
PMID: 11137582
A complete prevention of clinical experimental autoimmune myasthenia gravis (EAMG) was observed in lymphotoxin (LT)-alpha deficient (LT-alpha(-/-)) mice compared to LT-alpha(+/+) mice when immunized with acetylcholine receptor. However, only a...
10.
Hjelmstrom P, Fjell J, Nakagawa T, Sacca R, Cuff C, Ruddle N
Am J Pathol
. 2000 Apr;
156(4):1133-8.
PMID: 10751336
Secondary lymphoid tissue chemokine (SLC) and B lymphocyte chemoattractant (BLC) are homing chemokines that have been implicated in the trafficking of lymphocytes and dendritic cells in lymphoid organs. Lymphotoxin-alpha (LTalpha),...