N Gerwin
Overview
Explore the profile of N Gerwin including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
797
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Recent Articles
1.
Gerwin N, Bendele A, Glasson S, Carlson C
Osteoarthritis Cartilage
. 2010 Sep;
18 Suppl 3:S24-34.
PMID: 20864021
Objective: During the development of disease-modifying osteoarthritis (OA) drugs, rat models of OA are frequently used for a first assessment of in vivo efficacy. The most efficacious compound in the...
2.
Aigner T, Cook J, Gerwin N, Glasson S, Laverty S, Little C, et al.
Osteoarthritis Cartilage
. 2010 Sep;
18 Suppl 3:S2-6.
PMID: 20864020
Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the...
3.
Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations
Aigner T, Gerwin N
Curr Drug Targets
. 2007 Feb;
8(2):377-85.
PMID: 17305515
Gene expression analysis including large scale gene expression profiling has become a very basic tool for investigating the pathogenesis of degenerative joint diseases as well as for the search of...
4.
Rudolphi K, Gerwin N, Verzijl N, van der Kraan P, van den Berg W
Osteoarthritis Cartilage
. 2003 Sep;
11(10):738-46.
PMID: 13129693
Objective: To study the effect of pralnacasan, the orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE), RU 36384/VRT-18858, on joint damage in two mouse models...
5.
Gerwin N, Gonzalo J, Lloyd C, Coyle A, Reiss Y, Banu N, et al.
Immunity
. 1999 Feb;
10(1):9-19.
PMID: 10023766
ICAM-2-deficient mice exhibit prolonged accumulation of eosinophils in lung interstitium concomitant with a delayed increase in eosinophil numbers in the airway lumen during the development of allergic lung inflammation. The...
6.
Ligos J, Gerwin N, Fernandez P, Gutierrez-Ramos J, Bernad A
Biochem Biophys Res Commun
. 1998 Aug;
249(2):380-4.
PMID: 9712705
We report the cloning of the full-length cDNA of a new murine protein kinase, mPKL12. The sequence reveals a 305-amino-acid protein that contains the characteristic subdomains of the kinase superfamily...
7.
Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, et al.
Blood
. 1997 Oct;
90(6):2217-33.
PMID: 9310473
CD44 is expressed in various isoforms on numerous cell types and tissues during embryogenesis and in the mature organism. CD44 may also be involved in tumor growth. To study the...
8.
Sultan A, Briones M, Gerwin N, Carroll M, NUSSENZWEIG V
Mol Biochem Parasitol
. 1997 Sep;
88(1-2):263-6.
PMID: 9274888
No abstract available.
9.
Gerwin N, Friedrich C, Rosen F, Gutierrez-Ramos J
Clin Exp Immunol
. 1996 Nov;
106(2):208-17.
PMID: 8918565
The gene for Wiskott-Aldrich syndrome (WAS) has been recently identified and cloned, but our knowledge of downstream events affected in WAS is limited to a few leucocyte cell surface molecules....
10.
Suzuki A, Andrew D, Gonzalo J, Fukumoto M, Spellberg J, HASHIYAMA M, et al.
Blood
. 1996 May;
87(9):3550-62.
PMID: 8611677
CD34 is expressed on the surface of hematopoietic stem/progenitor cells, stromal cells, and on the surface of high-endothelial venules (HEV). CD34 binds L-selectin, an adhesion molecule important for leukocyte rolling...