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N F Nichols

Explore the profile of N F Nichols including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 245
Followers 0
Related Specialties
Pharmacology
Chemistry
Biochemistry
Top 10 Co-Authors
K A Svensson
J N Duncan
M W Smith
P J Schreur
A Carlsson
J Wijsman
S Wright
D K Hyslop
M Schoor
M F Lipton
Published In
J Med Chem
Pharmacol Biochem Behav
Neuropharmacology
Hum Mol Genet
Affiliations
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Recent Articles
1.
PNU-96391A (OSU6162) antagonizes the development of behavioral sensitization induced by dopamine agonists in a rat model for Parkinson's disease
Nichols N, Cimini M, Haas J, Staton B, Tedroff J, Svensson K
Neuropharmacology . 2002 Oct; 43(5):817-24. PMID: 12384167
PNU-96391A is a weak dopamine (DA) D(2) receptor antagonist with behavioral stabilizing properties. Previous experiments revealed that PNU-96391A antagonizes the expression of L-DOPA induced behavioral sensitization (dyskinesias) in lesioned primates...
2.
Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans
Cleek K, Dinh D, Duncan J, Haber C, Huff R, Lajiness M, et al.
J Med Chem . 2001 Dec; 44(26):4716-32. PMID: 11741489
5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective dopamine D(3) receptor antagonist with potential antipsychotic properties in animal models. To investigate the effects of nitrogen substitution on structure-activity relationships,...
3.
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
Roberds S, Anderson J, Basi G, Bienkowski M, Branstetter D, Chen K, et al.
Hum Mol Genet . 2001 Jun; 10(12):1317-24. PMID: 11406613
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. The major components of plaque, beta-amyloid peptides (Abetas), are produced from...
4.
Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites
Heier R, Dolak L, Duncan J, Hyslop D, Lipton M, Martin I, et al.
J Med Chem . 1997 Feb; 40(5):639-46. PMID: 9057850
The imidazoquinoline (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine [(R)-3] is a potent dopamine agonist when tested in animals but surprisingly shows very low affinity in in vitro binding assays. When incubated with mouse or monkey...
5.
Two automated locomotor activity tests for dopamine autoreceptor agonists
Schreur P, Nichols N
Pharmacol Biochem Behav . 1986 Jul; 25(1):255-61. PMID: 2875471
In the first test (exploratory activity), pretreated rats explored a novel environment in the dark. The potential autoreceptor agonists apomorphine HCl, N-n-propylnorapomorphine (NPA), and N-n-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) and its enantiomers decreased...