J N Duncan
Overview
Explore the profile of J N Duncan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
45
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Goad L, Breen M, Rendell N, Rose M, Duncan J, Wade A
Lipids
. 2016 Aug;
17(12):982-91.
PMID: 27519440
A simple method is described for the preparation of [6,7,7(-2)H3] sterols and steroids. The synthesis starts with a Δ(5)-sterol or steroid and involves preparation of the 6-oxo-3α,5α-cyclosteroid, base exchange in...
2.
Cleek K, Dinh D, Duncan J, Haber C, Huff R, Lajiness M, et al.
J Med Chem
. 2001 Dec;
44(26):4716-32.
PMID: 11741489
5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective dopamine D(3) receptor antagonist with potential antipsychotic properties in animal models. To investigate the effects of nitrogen substitution on structure-activity relationships,...
3.
Schlachter S, Poel T, Lawson C, Dinh D, Lajiness M, Romero A, et al.
Eur J Pharmacol
. 1997 Mar;
322(2-3):283-6.
PMID: 9098699
We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D1 receptor. Both compounds, 3-ethoxy-N-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-2-pyridinylamine (U-99363E), and its 3-isopropoxy analog (U-101958), were...
4.
Heier R, Dolak L, Duncan J, Hyslop D, Lipton M, Martin I, et al.
J Med Chem
. 1997 Feb;
40(5):639-46.
PMID: 9057850
The imidazoquinoline (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine [(R)-3] is a potent dopamine agonist when tested in animals but surprisingly shows very low affinity in in vitro binding assays. When incubated with mouse or monkey...
5.
TenBrink R, Bergh C, Duncan J, Harris D, Huff R, Lahti R, et al.
J Med Chem
. 1996 Jun;
39(13):2435-7.
PMID: 8691438
No abstract available.
6.
Sonesson C, Barf T, Nilsson J, Dijkstra D, Carlsson A, Svensson K, et al.
J Med Chem
. 1995 Apr;
38(8):1319-29.
PMID: 7731017
In order to explore further the structure-activity relationships of serotonergic and dopaminergic ligands, a series of enantiopure 5-, 7-, or 8-triflate (-OTf)-substituted 2-(monopropylamino)-tetralins have been synthesized and evaluated in in...
7.
Sonesson C, Boije M, Svensson K, Ekman A, Carlsson A, Romero A, et al.
J Med Chem
. 1993 Oct;
36(22):3409-16.
PMID: 8230131
The racemic triflate derivatives 5-8 of the 5-, 6-, 7-, and 8-hydroxylated 2-(di-n-propylamino)-teralins 1-4 were shown to possess similar pharmacological profiles to their phenolic counterparts in in vitro binding and...
8.
Duncan J, Parton T, Enos T
Biochem Soc Trans
. 1990 Dec;
18(6):1200-1.
PMID: 2088864
No abstract available.
9.
Duncan J, Davis J, Wade A, Walker S
Eur J Cancer Clin Oncol
. 1981 Oct;
17(10):1133-42.
PMID: 7200021
No abstract available.