N E Seidel
Overview
Explore the profile of N E Seidel including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
156
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Recent Articles
1.
Sabatino D, Seidel N, Cline A, Anderson S, Gallagher P, Bodine D
Ann N Y Acad Sci
. 2001 Jul;
938:246-61.
PMID: 11458514
Gene therapy for patients with hemoglobin disorders such has been hampered by the inability of retrovirus vectors to transfer globin genes and the locus control region (LCR) into hematopoietic stem...
2.
Aviles Mendoza G, Seidel N, Otsu M, Anderson S, Herrera A, Malech H, et al.
Mol Ther
. 2001 Apr;
3(4):565-73.
PMID: 11319919
X-linked severe combined immunodeficiency (XSCID) is caused by mutations in the IL-2 receptor gamma chain (IL2RG) gene, resulting in absent T lymphocytes and nonfunctional B lymphocytes. Recently T lymphocyte production...
3.
Barrette S, Douglas J, Seidel N, Bodine D
Blood
. 2000 Nov;
96(10):3385-91.
PMID: 11071632
The low levels of transduction of human hematopoietic stem cells (HSCs) with Moloney murine leukemia virus (MLV) vectors have been an obstacle to gene therapy for hematopoietic diseases. It has...
4.
Sabatino D, Seidel N, Cline A, Anderson S, Gallagher P, Bodine D
Proc Natl Acad Sci U S A
. 2000 Nov;
97(24):13294-9.
PMID: 11069298
Gene therapy for patients with hemoglobin disorders has been hampered by the inability of retrovirus vectors to transfer globin genes and their cis-acting regulatory sequences into hematopoietic stem cells without...
5.
Barrette S, Douglas J, Orlic D, Anderson S, Seidel N, Miller A, et al.
Mol Ther
. 2000 Aug;
1(4):330-8.
PMID: 10933951
The inefficient transduction of human hematopoietic stem cells (HSC) with amphotropic retroviral vectors has been an obstacle to gene therapy for hematopoietic diseases. We have previously reported low levels of...
6.
Whitwam T, Haskins M, Henthorn P, Kraszewski J, Kleiman S, Seidel N, et al.
Blood
. 1998 Aug;
92(5):1565-75.
PMID: 9716584
Optimization of retroviral gene transfer into hematopoietic cells of the dog will facilitate gene therapy of canine X-linked severe combined immunodeficiency (XSCID) and in turn advance similar efforts to treat...
7.
Bodine D, Dunbar C, GIRARD L, Seidel N, Cline A, Donahue R, et al.
Ann N Y Acad Sci
. 1998 Jul;
850:139-50.
PMID: 9668536
The efficiency of amphotropic retrovirus-mediated gene transfer into human Hematopoietic Stem Cells (HSC) is less than 1%. This has impeded gene therapy for hematopoietic diseases. In this study we demonstrate...
8.
Sabatino D, Do B, Pyle L, Seidel N, GIRARD L, Spratt S, et al.
Blood Cells Mol Dis
. 1998 Feb;
23(3):422-33.
PMID: 9454686
The low level of amphotropic retrovirus mediated gene transfer into human hematopoietic stem cells (HSC) has been an impediment to gene therapy for hematopoietic diseases (1). We have previously shown...
9.
Orlic D, GIRARD L, Anderson S, Do B, Seidel N, Jordan C, et al.
Stem Cells
. 1997 Jan;
15 Suppl 1:23-8; discussion 28-9.
PMID: 9368321
The low transduction efficiency of hematopoietic stem cells (HSC) using amphotropic retroviruses continues to plague gene therapy protocols. This low transduction efficiency may be related to a low level of...
10.
Dunbar C, Seidel N, Doren S, Sellers S, Cline A, Metzger M, et al.
Proc Natl Acad Sci U S A
. 1996 Oct;
93(21):11871-6.
PMID: 8876230
In previous studies we showed that 5 days of treatment with granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) mobilized murine repopulating cells to the peripheral blood (PB) and...