N C de Souza-Pinto
Overview
Explore the profile of N C de Souza-Pinto including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
505
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Panduri V, Liu G, Surapureddi S, Kondapalli J, Soberanes S, de Souza-Pinto N, et al.
Free Radic Biol Med
. 2009 Jun;
47(6):750-9.
PMID: 19524665
8-Oxoguanine DNA glycosylase (Ogg1) repairs 8-oxo-7,8-dihydroxyguanine (8-oxoG), one of the most abundant DNA adducts caused by oxidative stress. In the mitochondria, Ogg1 is thought to prevent activation of the intrinsic...
2.
Weissman L, de Souza-Pinto N, Stevnsner T, Bohr V
Neuroscience
. 2006 Nov;
145(4):1318-29.
PMID: 17092652
Accumulation of nuclear and mitochondrial DNA damage is thought to be particularly deleterious in post-mitotic cells, which cannot be replaced through cell division. Recent experimental evidence demonstrates the importance of...
3.
Stuart J, Bourque B, de Souza-Pinto N, Bohr V
Free Radic Biol Med
. 2005 Feb;
38(6):737-45.
PMID: 15721984
Accumulation of high levels of mutagenic oxidative mitochondrial DNA (mtDNA) lesions like 8-oxodeoxyguanine (8-oxodG) is thought to be involved in the development of mitochondrial dysfunction in aging and in disorders...
4.
Hashiguchi K, Stuart J, de Souza-Pinto N, Bohr V
Nucleic Acids Res
. 2004 Oct;
32(18):5596-608.
PMID: 15494448
The human Ogg1 glycosylase is responsible for repairing 8-oxo-7,8-dihydroguanine (8-oxoG) in both nuclear and mitochondrial DNA. Two distinct Ogg1 isoforms are present; alpha-Ogg1, which mainly localizes to the nucleus and...
5.
Gabrielson K, Hogue B, Bohr V, Cardounel A, Nakajima W, Kofler J, et al.
Am J Pathol
. 2001 Oct;
159(4):1507-20.
PMID: 11583977
We investigated the effects of 3-nitropropionic acid (3NPA), a previously characterized neurotoxin, in four strains of mice to better understand the molecular basis of variable host responses to this agent....
6.
de Souza-Pinto N, Eide L, Hogue B, Thybo T, Stevnsner T, Seeberg E, et al.
Cancer Res
. 2001 Jul;
61(14):5378-81.
PMID: 11454679
Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative damage. One of the major products of DNA...
7.
de Souza-Pinto N, Hogue B, Bohr V
Free Radic Biol Med
. 2001 Apr;
30(8):916-23.
PMID: 11295534
8-oxo-deoxyguanosine (8-oxodG) is one of the major DNA lesions formed upon oxidative attack of DNA. It is a mutagenic adduct that has been associated with pathological states such as cancer...
8.
Kirsch D, Doseff A, Chau B, Lim D, de Souza-Pinto N, Hansford R, et al.
J Biol Chem
. 1999 Jul;
274(30):21155-61.
PMID: 10409669
Caspases are cysteine proteases that mediate apoptosis by proteolysis of specific substrates. Although many caspase substrates have been identified, for most substrates the physiologic caspase(s) required for cleavage is unknown....
9.
de Souza-Pinto N, Vercesi A, Hoffmann M
Free Radic Biol Med
. 1996 Jan;
20(5):657-66.
PMID: 8721612
In this work we investigated the toxicity of a polyphenolic p-benzoquinone derivative, the tetrahydroxy-1,4-quinone (THQ) toward V79 Chinese hamster fibroblasts and analyzed the role of H2O2 and Ca2+ in that...