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N C Barnes

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Recent Articles
11.
Gamble E, Qiu Y, Wang D, Zhu J, Vignola A, Kroegel C, et al.
Eur Respir J . 2006 Feb; 27(2):293-9. PMID: 16452583
There is variability in the distribution of inflammatory cells in bronchial tissue in chronic obstructive pulmonary disease (COPD). Better strategies for biopsy sampling of the airway mucosa may improve the...
12.
Barnes N, Powell M, Trist H, Gavin A, Wines B, Hogarth P
Immunol Lett . 2005 Dec; 104(1-2):118-23. PMID: 16375976
Ligand-dependent aggregation of FcgammaRIIa initiates multiple biochemical processes including the translocation to detergent resistant membrane domains (DRMs) and receptor tyrosine phosphorylation. Palmitoylation of cysteine residues is considered to be one...
13.
Barnes N, Williams A
Int J Clin Pract . 2005 Aug; 59(9):1017-24. PMID: 16115175
This survey describes asthma control and unscheduled healthcare resource use (HCRU) among patients receiving low-dose inhaled corticosteroids (ICS) alone in five European countries and the USA. Physicians and patients completed...
14.
Elston W, Whittaker A, Khan L, Flood-Page P, Ramsay C, Jeffery P, et al.
Eur Respir J . 2004 Sep; 24(3):375-7. PMID: 15358694
Bronchoscopy with endobronchial biopsy (EBB) and/or bronchoalveolar lavage (BAL) has become an important research tool in asthma. A recent report has suggested audit and reporting of the safety of these...
15.
Gamble E, Burns W, Zhu J, Ansari T, De Rose V, Kips J, et al.
Eur Respir J . 2003 Dec; 22(6):992-5. PMID: 14680091
The variation of CD8+ cells has been determined around the internal perimeter of intrapulmonary bronchi in smokers with chronic bronchitis (CB), and the amount of tissue required to confidently estimate...
16.
Ram F, Wellington S, Barnes N
Cochrane Database Syst Rev . 2003 Oct; (4):CD003792. PMID: 14583993
Background: In moderate to severe chronic obstructive pulmonary disease there is good evidence of a generalised loss of muscle bulk (including the respiratory muscles). It is possible that similar loss...
17.
Ying S, Khan L, Meng Q, Barnes N, Kay A
Eur Respir J . 2003 Sep; 22(2):207-12. PMID: 12952249
The late asthmatic reaction is characterised by elevated numbers of interleukin-4/interleukin-5/CD4-positive T-helper cells type 2 in bronchoalveolar lavage fluid (BALF). Cyclosporin A (CsA) is known to inhibit T-cell proliferation, induce...
18.
Barnes S, Wang C, Kirk M, Smith-Johnson M, Coward L, Barnes N, et al.
Adv Exp Med Biol . 2002 Jun; 505:77-88. PMID: 12083468
No abstract available.
19.
Kon O, Sihra B, Loh L, Barkans J, Compton C, Barnes N, et al.
Eur Respir J . 2001 Aug; 18(1):45-52. PMID: 11510804
CD4+ T-cells are likely to be involved as a source of pro-inflammatory cytokines in asthma. This study assessed the effects of an infusion of keliximab (IDEC CE9.1), an anti-CD4+ monoclonal...
20.
Compton C, Gubb J, NIEMAN R, Edelson J, Amit O, Bakst A, et al.
Lancet . 2001 Aug; 358(9278):265-70. PMID: 11498212
Background: Chronic obstructive pulmonary disease (COPD) is a common, progressive respiratory disease that causes great morbidity and mortality despite treatment. There is evidence for airway inflammation in COPD. Cilomilast is...