N Brouwer
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Explore the profile of N Brouwer including associated specialties, affiliations and a list of published articles.
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28
Citations
640
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Recent Articles
11.
Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo
Dijkstra I, de Haas A, Brouwer N, Boddeke H, Biber K
Glia
. 2006 Sep;
54(8):861-72.
PMID: 16977602
Since activated microglia are able to phagocytose damaged cells and subsequently express major histocompatibility complex class II (MHC-II) and co-stimulatory proteins, they are considered to function as antigen presenting cells...
12.
Frakking F, Brouwer N, Zweers D, Merkus M, Kuijpers T, Offringa M, et al.
Clin Exp Immunol
. 2006 Jun;
145(1):5-12.
PMID: 16792667
Mannose-binding lectin (MBL) is a component of innate immunity and thus particularly important in neonates in whom adaptive immunity is not yet completely developed. Promoter polymorphisms and structural exon-1 mutations...
13.
Frakking F, van de Wetering M, Brouwer N, Dolman K, Geissler J, Lemkes B, et al.
Eur J Cancer
. 2006 Mar;
42(7):909-16.
PMID: 16517152
Children with cancer often have fever during chemotherapy-induced neutropenia, but only some develop serious infectious complications. Mannose-binding lectin (MBL) deficiency might increase infection susceptibility in these children. MBL genotype and...
14.
Brouwer N, Zuurman M, Wei T, Ransohoff R, Boddeke H, Biber K
Glia
. 2004 Mar;
46(1):84-94.
PMID: 14999816
Chemokines and chemokine receptors are important regulators of leukocyte trafficking and immune response. It is well established that chemokines and their receptors are also expressed in the central nervous system...
15.
Kust B, Brouwer N, Mantingh I, Boddeke H, Copray J
Amyotroph Lateral Scler Other Motor Neuron Disord
. 2003 Sep;
4(2):100-5.
PMID: 14506941
hSOD1 (G93A) transgenic mice develop pathological changes similar to those in patients with familial amyotrophic lateral sclerosis (FALS). In particular, the progressive degeneration of motoneurons is charactered in this mouse...
16.
Copray J, Jaarsma D, Kust B, Bruggeman R, Mantingh I, Brouwer N, et al.
Neuroscience
. 2003 Feb;
116(3):685-94.
PMID: 12573711
Amyotrophic lateral sclerosis is a lethal neurodegenerative disorder involving motoneuron loss in the cortex, brainstem and spinal cord, resulting in progressive paralysis. Aberrant neurotrophin signalling via the low affinity neurotrophin...
17.
Kust B, Copray J, Brouwer N, Troost D, Boddeke H
Exp Neurol
. 2002 Nov;
177(2):419-27.
PMID: 12429188
Previous studies suggest that neurotrophins support regeneration and survival of injured motoneurons. Based on these findings, brain-derived neurotrophic factor (BDNF) has been clinically investigated for its therapeutic potential in amyotrophic...
18.
Biber K, Rappert A, Kettenmann H, Brouwer N, Copray S, Boddeke H
Ernst Schering Res Found Workshop
. 2002 Jun;
(39):45-60.
PMID: 12066416
No abstract available.
19.
Liem R, Brouwer N, Copray J
Histochem Cell Biol
. 2002 Jan;
116(6):545-51.
PMID: 11810196
A non-radioactive in situ hybridisation method is described for the detection of low intramuscular levels of brain-derived neurotrophic factor (BDNF) mRNA at the electron microscope level. Application of high-grade silver-gold...
20.
Copray J, Mantingh I, Brouwer N, Biber K, Kust B, Liem R, et al.
J Neuroimmunol
. 2001 Aug;
118(2):203-11.
PMID: 11498255
The expression of interleukin-1beta was examined in dorsal root ganglion (DRG) neurons from adult rats using non-radioactive in situ hybridization and immunocytochemistry. At all spinal levels, approximately 70% of the...