N B Higgs
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Explore the profile of N B Higgs including associated specialties, affiliations and a list of published articles.
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22
Citations
232
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Recent Articles
1.
Stephens R, Tanianis-Hughes J, Higgs N, Humphrey M, Warhurst G
J Pharmacol Exp Ther
. 2002 Nov;
303(3):1095-101.
PMID: 12438532
Information on the extent to which xenobiotics interact with P-glycoprotein (PGP) during transit through the intestine is crucial in determining the influence of PGP on oral drug absorption. We have...
2.
Emery P, Higgs N, Warhurst A, Carlson G, Warhurst G
Br J Pharmacol
. 2002 Mar;
135(6):1443-8.
PMID: 11906957
1. The diverse physiological actions of somatostatin are mediated by a family of G-protein coupled receptors (SSTRs). Several peptide analogues of somatostatin such as octreotide have been developed for therapeutic...
3.
Sandle G, Warhurst G, Butterfield I, Higgs N, Lomax R
Am J Physiol
. 1999 Nov;
277(5):G967-75.
PMID: 10564102
Somatostatin is a powerful inhibitor of intestinal Cl(-) secretion. We used patch-clamp recording techniques to investigate the effects of somatostatin on low-conductance (23-pS) K(+) channels in the basolateral membrane of...
4.
Sandle G, Butterfield I, Higgs N, Warhurst G
Pflugers Arch
. 1999 Mar;
437(4):596-602.
PMID: 10089573
The most abundant basolateral K+ channels in human colonic crypt cells have a low conductance (23 pS), respond to increases in intracellular Ca2+ and cAMP, and have been implicated in...
5.
Collett A, Higgs N, Sims E, Rowland M, Warhurst G
J Pharmacol Exp Ther
. 1998 Dec;
288(1):171-8.
PMID: 9862768
The influence of secretory transporters on intestinal permeability characteristics of the H2 receptor antagonists ranitidine and cimetidine was studied in Caco-2 monolayers and rat intestinal mucosa mounted in Ussing chambers....
6.
Warhurst G, Higgs N, Fakhoury H, Warhurst A, Garde J, Coy D
Gastroenterology
. 1996 Aug;
111(2):325-33.
PMID: 8690197
Background & Aims: Somatostatin peptides are potent inhibitors of intestinal ion secretion, providing the rationale for their use in treating secretory diarrhea. However, the nature of the receptors that mediate...
7.
Warhurst G, Barbezat G, Higgs N, Reyl-Desmars F, Lewin M, Coy D, et al.
Am J Physiol
. 1995 Nov;
269(5 Pt 1):G729-36.
PMID: 7491965
Recent studies in a cultured model of the intestinal epithelium (HT-29cl.19A) have shown that somatostatin-14 (SS-14) inhibits the Cl- secretory process by acting at multiple G protein-dependent sites. These actions...
8.
Warhurst G, Higgs N, Grigor M, Ross I, Barbezat G
Biochem Soc Trans
. 1995 Feb;
23(1):18S.
PMID: 7758725
No abstract available.
9.
Fogg K, Higgs N, Warhurst G
Biochim Biophys Acta
. 1994 Mar;
1221(2):185-92.
PMID: 8148397
The receptor-mediated agonist, neurotensin (NT) stimulated Ba(2+)- and charybdotoxin-sensitive 86Rb (K+) efflux in the HT29-19A colonic cell line. Efflux was also stimulated by ionomycin and thapsigargin and could be abolished...
10.
Warhurst G, Fogg K, Higgs N, Tonge A, Grundy J
Cell Calcium
. 1994 Feb;
15(2):162-74.
PMID: 8149416
This study has examined the involvement of the Ca(2+)-signalling pathway in the regulation of agonist-stimulated cAMP responses in the human colonic adenocarcinoma cell line, HT29-cl.19A. The muscarinic agonist, carbachol (CCh)...