N A Hotchin
Overview
Explore the profile of N A Hotchin including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
872
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Recent Articles
1.
Scales T, Jayo A, Obara B, Holt M, Hotchin N, Berditchevski F, et al.
Oncogene
. 2012 Sep;
32(34):3965-79.
PMID: 22986527
Integrins are extracellular matrix (ECM) receptors that are key players in the regulation of tumour cell invasion. The laminin-binding integrin α3β1 has previously been shown to regulate adhesion and migration...
2.
Brookes M, Boult J, Roberts K, Cooper B, Hotchin N, Matthews G, et al.
Oncogene
. 2007 Aug;
27(7):966-75.
PMID: 17700530
There is an emerging body of evidence implicating iron in carcinogenesis and in particular colorectal cancer, but whether this involves Wnt signalling, a major oncogenic signalling pathway has not been...
3.
GILES K, Ross K, Rossi A, Hotchin N, Haslett C, Dransfield I
J Immunol
. 2001 Jul;
167(2):976-86.
PMID: 11441106
Phagocytic clearance of apoptotic granulocytes has a pivotal role in determining an inflammatory outcome, resolution or progression to a chronic state associated with development of fibrotic repair mechanisms, and/or autoimmune...
4.
Akhtar N, Hotchin N
Mol Biol Cell
. 2001 Apr;
12(4):847-62.
PMID: 11294891
The establishment of cadherin-dependent cell-cell contacts in human epidermal keratinocytes are known to be regulated by the Rac1 small GTP-binding protein, although the mechanisms by which Rac1 participates in the...
5.
Akhtar N, Hudson K, Hotchin N
Cell Adhes Commun
. 2000 Oct;
7(6):465-76.
PMID: 11051457
The Rac1 small GTP-binding protein is known to be involved in reorganization of the actin cytoskeleton and in regulation of intracellular signal transduction. The assembly and maintenance of cadherin-based cell...
6.
Anderson S, Hotchin N, Nash G
J Cell Sci
. 2000 Jul;
113 ( Pt 15):2737-45.
PMID: 10893189
When rolling adherent neutrophils are stimulated, they rapidly immobilize through activation of integrin CD11b/CD18, and then modulate attachment through this integrin to allow migration. We investigated links between cytoskeletal rearrangement...
7.
Knight B, Laukaitis C, Akhtar N, Hotchin N, Edlund M, Horwitz A
Curr Biol
. 2000 Jun;
10(10):576-85.
PMID: 10837222
Background: Cell migration has been studied extensively by manipulating and observing cells bathed in putative chemotactic or chemokinetic agents on planar substrates. This environment differs from that in vivo and,...
8.
Hotchin N, Cover T, Akhtar N
J Biol Chem
. 2000 Apr;
275(19):14009-12.
PMID: 10747859
Chronic gastric infection with the Gram-negative bacterium Helicobacter pylori is a major contributing factor in the development of duodenal ulcers and is believed to be a significant risk factor in...
9.
Hotchin N, Kidd A, Altroff H, Mardon H
J Cell Sci
. 1999 Aug;
112 (Pt 17):2937-46.
PMID: 10444388
Fibronectins are widely expressed extracellular matrix ligands that are essential for many biological processes. Fibronectin-induced signaling pathways are elicited in diverse cell types when specific integrin receptors bind to the...
10.
BRAGA V, Machesky L, Hall A, Hotchin N
J Cell Biol
. 1997 Jun;
137(6):1421-31.
PMID: 9182672
Cadherins are calcium-dependent cell-cell adhesion molecules that require the interaction of the cytoplasmic tail with the actin cytoskeleton for adhesive activity. Because of the functional relationship between cadherin receptors and...