Mykhaylo V Ruchko
Overview
Explore the profile of Mykhaylo V Ruchko including associated specialties, affiliations and a list of published articles.
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13
Citations
329
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Recent Articles
1.
Yuzefovych L, Pastukh V, Ruchko M, Simmons J, Richards W, Rachek L
PLoS One
. 2019 Oct;
14(10):e0222278.
PMID: 31600210
Cells damaged by mechanical or infectious injury release proinflammatory mitochondrial DNA (mtDNA) fragments into the circulation. We evaluated the relation between plasma levels of mtDNA fragments in obese type 2...
2.
Bradley J, Li Z, Organ C, Polhemus D, Otsuka H, Islam K, et al.
Am J Physiol Heart Circ Physiol
. 2017 Nov;
314(2):H311-H321.
PMID: 29101177
Oxidative stress results in mtDNA damage and contributes to myocardial cell death. mtDNA repair enzymes are crucial for mtDNA repair and cell survival. We investigated a novel, mitochondria-targeted fusion protein...
3.
Lee Y, Obiako B, Gorodnya O, Ruchko M, Kuck J, Pastukh V, et al.
Shock
. 2017 Jan;
48(1):54-60.
PMID: 28125528
Although studies in rat cultured pulmonary artery endothelial cells, perfused lungs, and intact mice support the concept that oxidative mitochondrial (mt) DNA damage triggers acute lung injury (ALI), it has...
4.
Pastukh V, Gorodnya O, Gillespie M, Ruchko M
Free Radic Biol Med
. 2016 Apr;
96:78-88.
PMID: 27091693
Mitochondria of mammalian cells contain multiple copies of mitochondrial (mt) DNA. Although mtDNA copy number can fluctuate dramatically depending on physiological and pathophysiologic conditions, the mechanisms regulating mitochondrial genome replication...
5.
Yang X, Cui L, White J, Kuck J, Ruchko M, Wilson G, et al.
Basic Res Cardiol
. 2015 Jan;
110(2):3.
PMID: 25595210
Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect...
6.
Hashizume M, Mouner M, Chouteau J, Gorodnya O, Ruchko M, Wilson G, et al.
Pharmaceuticals (Basel)
. 2014 Aug;
7(8):894-912.
PMID: 25153040
The mitochondrial targeted DNA repair enzyme, 8-oxoguanine DNA glycosylase 1, was previously reported to protect against mitochondrial DNA (mtDNA) damage and ventilator induced lung injury (VILI). In the present study...
7.
Hashizume M, Mouner M, Chouteau J, Gorodnya O, Ruchko M, Potter B, et al.
Am J Physiol Lung Cell Mol Physiol
. 2012 Dec;
304(4):L287-97.
PMID: 23241530
This study tested the hypothesis that oxidative mitochondrial-targeted DNA (mtDNA) damage triggered ventilator-induced lung injury (VILI). Control mice and mice infused with a fusion protein targeting the DNA repair enzyme,...
8.
Chouteau J, Obiako B, Gorodnya O, Pastukh V, Ruchko M, Wright A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2011 Sep;
301(6):L892-8.
PMID: 21890512
In cultured pulmonary artery endothelial cells and other cell types, overexpression of mt-targeted DNA repair enzymes protects against oxidant-induced mitochondrial DNA (mtDNA) damage and cell death. Whether mtDNA integrity governs...
9.
Pastukh V, Zhang L, Ruchko M, Gorodnya O, Bardwell G, Tuder R, et al.
Int J Chron Obstruct Pulmon Dis
. 2011 Jun;
6:209-17.
PMID: 21660298
Lung tissue from COPD patients displays oxidative DNA damage. The present study determined whether oxidative DNA damage was randomly distributed or whether it was localized in specific sequences in either...
10.
Ruchko M, Gorodnya O, Zuleta A, Pastukh V, Gillespie M
Free Radic Biol Med
. 2010 Oct;
50(9):1107-13.
PMID: 20969951
Emerging evidence suggests that mitochondrial (mt) DNA damage may be a trigger for apoptosis in oxidant-challenged pulmonary artery endothelial cells (PAECs). Understanding the rate-limiting determinants of mtDNA repair may point...