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Mukulika Ray

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Recent Articles
1.
Mahableshwarkar P, Shum J, Ray M, Larschan E
Bioinformatics . 2024 Nov; 40(11. PMID: 39520544
Summary: Advanced genomic technologies have generated thousands of protein-nucleic acid binding datasets that have the potential to identify testable gene regulatory network (GRNs) models governed by combinatorial associations between factors....
2.
Ray M, Zaborowsky J, Mahableshwarkar P, Vaidyanathan S, Shum J, Viswanathan R, et al.
bioRxiv . 2024 Jan; PMID: 38260450
Despite decades of research, mechanisms by which co-transcriptional alternative splicing events are targeted to the correct genomic locations to drive cell fate decisions remain unknown. By combining structural and molecular...
3.
Aguilera J, Duan J, Lee S, Ray M, Larschan E
bioRxiv . 2023 Oct; PMID: 37873306
In order to survive when exposed to heat stress (HS), organisms activate stress response genes and repress constitutive gene expression to prevent the accumulation of potentially toxic RNA and protein...
4.
Ray M, Conard A, Urban J, Mahableshwarkar P, Aguilera J, Huang A, et al.
Elife . 2023 Jul; 12. PMID: 37466240
Sex-specific splicing is an essential process that regulates sex determination and drives sexual dimorphism. Yet, how early in development widespread sex-specific transcript diversity occurs was unknown because it had yet...
5.
Ray M, Larschan E
Genes Dev . 2020 May; 34(9-10):619-620. PMID: 32358039
In this issue of , Lu and colleagues (pp. 663-677) have discovered a key new mechanism of alternative promoter choice that is involved in differentiation of spermatocytes. Promoter choice has...
6.
Ray M, Lakhotia S
Dev Dyn . 2019 Aug; 248(12):1211-1231. PMID: 31415125
Background: Dilp8-mediated inhibition of ecdysone synthesis and pupation in holometabolous insects maintains developmental homeostasis through stringent control of timing and strength of molting signals. We examined reasons for normal pupation...
7.
Ray M, Acharya S, Shambhavi S, Lakhotia S
J Biosci . 2019 Jun; 44(2). PMID: 31180049
We examined interactions between the 83 kDa heat-shock protein (Hsp83) and long noncoding RNAs (lncRNAs) in Hsp90GFP homozygotes, which almost completely lack lncRNAs but over-express Hsp83. All +/+; Hsp90GFP progeny...
8.
Ray M, Singh G, Lakhotia S
Gene Expr Patterns . 2019 May; 33:20-36. PMID: 31096022
We exploited the high Ras activity induced differentiation of supernumerary R7 cells in Drosophila eyes to examine if hsrω lncRNAs influence active Ras signaling. Surprisingly, either down- or up-regulation of...
9.
Ray M, Lakhotia S
J Genet . 2015 Oct; 94(3):407-16. PMID: 26440079
The binary GAL4-UAS system of conditional gene expression is widely used by Drosophila geneticists to target expression of the desired transgene in tissue of interest. In many studies, a preferred...
10.
Lakhotia S, Mallik M, Singh A, Ray M
Chromosoma . 2011 Sep; 121(1):49-70. PMID: 21913129
The hs-GAL4(t)-driven expression of the hsrω-RNAi transgene or EP93D allele of the noncoding hsrω resulted in global down- or upregulation, respectively, of the large hsrω-n transcripts following heat shock. Subsequent...