Muhammad Rizwan Alam
Overview
Explore the profile of Muhammad Rizwan Alam including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
410
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Recent Articles
11.
Ferrera R, Benhabbouche S, Crola Da Silva C, Alam M, Ovize M
J Thorac Cardiovasc Surg
. 2015 Sep;
150(6):1641-8.e2.
PMID: 26384749
Objectives: The aims of this study were to evaluate whether the delayed application of low-pressure reperfusion could reduce lethal reperfusion injury and whether the inhibition of the opening of the...
12.
Alam M, Baetz D, Ovize M
J Mol Cell Cardiol
. 2014 Oct;
78:80-9.
PMID: 25281838
Reperfusion is characterized by a deregulation of ion homeostasis and generation of reactive oxygen species that enhance the ischemia-related tissue damage culminating in cell death. The mitochondrial permeability transition pore...
13.
Groschner L, Alam M, Graier W
Vitam Horm
. 2014 Feb;
95:63-86.
PMID: 24559914
Pancreatic β-cells are the only cells capable of lowering blood glucose by secreting insulin. The β-cell continuously adjusts its secretory activity to substrate availability in order to keep blood glucose...
14.
Bondarenko A, Jean-Quartier C, Parichatikanond W, Alam M, Waldeck-Weiermair M, Malli R, et al.
Pflugers Arch
. 2013 Oct;
466(7):1411-20.
PMID: 24162235
A protein referred to as CCDC109A and then renamed to mitochondrial calcium uniporter (MCU) has recently been shown to accomplish mitochondrial Ca(2+) uptake in different cell types. In this study,...
15.
Waldeck-Weiermair M, Deak A, Groschner L, Alam M, Jean-Quartier C, Malli R, et al.
J Biol Chem
. 2013 Apr;
288(21):15367-79.
PMID: 23592775
The transfer of Ca(2+) across the inner mitochondrial membrane is an important physiological process linked to the regulation of metabolism, signal transduction, and cell death. While the definite molecular composition...
16.
Deak A, Groschner L, Alam M, Seles E, Bondarenko A, Graier W, et al.
J Cell Sci
. 2012 Dec;
126(Pt 4):879-88.
PMID: 23239024
The endocannabiniod anandamide (AEA) and its derivate N-arachidonoyl glycine (NAGly) have a broad spectrum of physiological effects, which are induced by both binding to receptors and receptor-independent modulations of ion...
17.
Waldeck-Weiermair M, Alam M, Jadoon Khan M, Deak A, Vishnu N, Karsten F, et al.
PLoS One
. 2012 Oct;
7(9):e45917.
PMID: 23029314
The transfer of Ca(2+) from the cytosol into the lumen of mitochondria is a crucial process that impacts cell signaling in multiple ways. Cytosolic Ca(2+) ([Ca(2+)](cyto)) can be excellently quantified...
18.
Alam M, Groschner L, Parichatikanond W, Kuo L, Bondarenko A, Rost R, et al.
J Biol Chem
. 2012 Aug;
287(41):34445-54.
PMID: 22904319
In pancreatic β-cells, uptake of Ca(2+) into mitochondria facilitates metabolism-secretion coupling by activation of various matrix enzymes, thus facilitating ATP generation by oxidative phosphorylation and, in turn, augmenting insulin release....
19.
Jadoon Khan M, Alam M, Waldeck-Weiermair M, Karsten F, Groschner L, Riederer M, et al.
J Biol Chem
. 2012 May;
287(25):21110-20.
PMID: 22556413
Accumulation of palmitic acid (PA) in cells from nonadipose tissues is known to induce lipotoxicity resulting in cellular dysfunction and death. The exact molecular pathways of PA-induced cell death are...
20.
Jean-Quartier C, Bondarenko A, Alam M, Trenker M, Waldeck-Weiermair M, Malli R, et al.
Mol Cell Endocrinol
. 2011 Nov;
353(1-2):114-27.
PMID: 22100614
Mitochondrial Ca(2+) sequestration is a well-known process that is involved in various physiological and pathological mechanisms. Using isolated suspended mitochondria one unique mitochondrial Ca(2+) uniporter was considered to account ubiquitously...