Mubarak I Umar
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Explore the profile of Mubarak I Umar including associated specialties, affiliations and a list of published articles.
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7
Citations
97
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Recent Articles
1.
Anastasakis D, Apostolidi M, Garman K, Polash A, Umar M, Meng Q, et al.
Mol Cell
. 2024 Aug;
84(19):3775-3789.e6.
PMID: 39153475
Nuclear localization of the metabolic enzyme PKM2 is widely observed in various cancer types. We identify nuclear PKM2 as a non-canonical RNA-binding protein (RBP) that specifically interacts with folded RNA...
2.
Umar M, Chan C, Kwok C
Nat Protoc
. 2022 Apr;
17(6):1385-1414.
PMID: 35444329
RNA G-quadruplex (rG4)-SELEX is a method that generates L-RNA aptamers to target an rG4 structure of interest, which can be applied to inhibit G-quadruplex-mediated interactions that have important roles in...
3.
Dumetz F, Chow E, Harris L, Liew S, Jensen A, Umar M, et al.
Nucleic Acids Res
. 2021 Nov;
49(21):12486-12501.
PMID: 34792144
G-quadruplexes are non-helical secondary structures that can fold in vivo in both DNA and RNA. In human cells, they can influence replication, transcription and telomere maintenance in DNA, or translation,...
4.
Umar M, Kwok C
Nucleic Acids Res
. 2020 Sep;
48(18):10125-10141.
PMID: 32976590
G-quadruplexes (G4s) are nucleic acid structure motifs that are of significance in chemistry and biology. The function of G4s is often governed by their interaction with G4-binding proteins. Few categories...
5.
Umar M, Ji D, Chan C, Kwok C
Molecules
. 2019 Jul;
24(13).
PMID: 31262059
Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play significant roles in various...
6.
Chan C, Umar M, Kwok C
Chem Commun (Camb)
. 2019 Feb;
55(18):2616-2619.
PMID: 30724299
Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged...
7.
Chan K, Peng B, Umar M, Chan C, Sahakyan A, Le M, et al.
Chem Commun (Camb)
. 2018 Sep;
54(77):10878-10881.
PMID: 30204160
Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in...