Structural Analysis Reveals the Formation and Role of RNA G-quadruplex Structures in Human Mature MicroRNAs

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Sep 12

PMID 30204160

Citations 24

Authors

Ka Lung Chan

Boya Peng

Mubarak I Umar

Chun-Yin Chan

Aleksandr B Sahakyan

Minh T N Le

Chun Kit Kwok

Affiliations

Soon will be listed here.

Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

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