Motonori Ota
Overview
Explore the profile of Motonori Ota including associated specialties, affiliations and a list of published articles.
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70
Citations
741
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Recent Articles
1.
Sakuma K, Chikenji G, Ota M
Methods Mol Biol
. 2024 Nov;
2870:79-93.
PMID: 39543032
We introduce our approach to analyzing the entire Protein Data Bank (PDB) by combining state-of-the-art bioinformatic tools. As an interesting case, we report sequence/conformation analysis of Walker-A motifs and β-α-β...
2.
Sakuma K, Koike R, Ota M
Protein Sci
. 2024 Mar;
33(4):e4934.
PMID: 38501460
AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure...
3.
Koike R, Ota M
Proteins
. 2023 Jul;
92(1):37-43.
PMID: 37497763
Capping protein (CP) binds to the barbed end of an actin-filament and inhibits its elongation. CARMIL binds CP and dissociates it from the barbed end of the actin-filament. The binding...
4.
Anbo H, Ota M, Fukuchi S
Methods Mol Biol
. 2023 Mar;
2627:231-245.
PMID: 36959451
Intrinsically disordered regions (IDRs) are protein regions that do not adopt fixed tertiary structures. Since these regions lack ordered three-dimensional structures, they should be excluded from the target portions of...
5.
Minami S, Niwa T, Uemura E, Koike R, Taguchi H, Ota M
FEBS Open Bio
. 2023 Mar;
13(4):779-794.
PMID: 36869604
Molecular chaperones are indispensable proteins that assist the folding of aggregation-prone proteins into their functional native states, thereby maintaining organized cellular systems. Two of the best-characterized chaperones are the Escherichia ...
6.
Anbo H, Sakuma K, Fukuchi S, Ota M
Biology (Basel)
. 2023 Feb;
12(2).
PMID: 36829461
AlphaFold2 (AF2) is a protein structure prediction program which provides accurate models. In addition to predicting structural domains, AF2 assigns intrinsically disordered regions (IDRs) by identifying regions with low prediction...
7.
Ozawa Y, Anbo H, Ota M, Fukuchi S
J Biochem
. 2022 Dec;
173(4):255-264.
PMID: 36575582
Liquid-liquid phase separation (LLPS) within the cell can form biological condensates, which are increasingly recognized to play important roles in various biological processes. Most proteins involved in LLPS are known...
8.
Kanematsu Y, Narita A, Oda T, Koike R, Ota M, Takano Y, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2122641119.
PMID: 36252034
The major cytoskeleton protein actin undergoes cyclic transitions between the monomeric G-form and the filamentous F-form, which drive organelle transport and cell motility. This mechanical work is driven by the...
9.
Hijikata A, Shionyu-Mitsuyama C, Nakae S, Shionyu M, Ota M, Kanaya S, et al.
FEBS Open Bio
. 2021 Dec;
12(1):285-294.
PMID: 34850606
Cepharanthine (CEP) is a natural biscoclaurine alkaloid of plant origin and was recently demonstrated to have anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activity. In this study, we evaluated whether...
10.
Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins
Hijikata A, Shionyu C, Nakae S, Shionyu M, Ota M, Kanaya S, et al.
Biophys Physicobiol
. 2021 Nov;
18:226-240.
PMID: 34745807
More than one and half years have passed, as of August 2021, since the COVID-19 caused by the novel coronavirus named SARS-CoV-2 emerged in 2019. While the recent success of...