Morghan C Lucas
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Explore the profile of Morghan C Lucas including associated specialties, affiliations and a list of published articles.
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26
Citations
1257
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Recent Articles
1.
Wendlandt M, Erdmann H, Rost S, Lucas M, Becker K, Kleinle S, et al.
Neurol Genet
. 2024 Dec;
11(1):e200220.
PMID: 39703464
Background And Objectives: Myotonic dystrophy type 2 (DM2) is a multisystemic repeat disorder caused by the expansion of an unstable CCTG tetranucleotide repeat in the noncoding region of the gene....
2.
Milenkovic I, Cruciani S, Llovera L, Lucas M, Medina R, Pauli C, et al.
Mol Cell
. 2024 Dec;
85(1):177-190.e7.
PMID: 39662470
Mammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with over 220 rRNA modifications. Previous works have shown that some rRNA modification types can be dynamically regulated; however, how...
3.
Diensthuber G, Pryszcz L, Llovera L, Lucas M, Delgado-Tejedor A, Cruciani S, et al.
Genome Res
. 2024 Sep;
34(11):1865-1877.
PMID: 39271295
In recent years, nanopore direct RNA sequencing (DRS) became a valuable tool for studying the epitranscriptome, owing to its ability to detect multiple modifications within the same full-length native RNA...
4.
Pereira B, Ritchie S, Chambers C, Gordon K, Magenau A, Murphy K, et al.
Sci Adv
. 2024 Jul;
10(27):eadl1197.
PMID: 38959305
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic...
5.
Chitty J, Yam M, Perryman L, Parker A, Skhinas J, Setargew Y, et al.
Nat Cancer
. 2023 Aug;
4(9):1326-1344.
PMID: 37640930
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its known...
6.
Lucas M, Pryszcz L, Medina R, Milenkovic I, Camacho N, Marchand V, et al.
Nat Biotechnol
. 2023 Apr;
42(1):72-86.
PMID: 37024678
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is...
7.
Milenkovic I, Santos Vieira H, Lucas M, Ruiz-Orera J, Patone G, Kesteven S, et al.
Nucleic Acids Res
. 2023 Mar;
51(11):5301-5324.
PMID: 36882085
The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged phenomenon. However, whether this heterogeneity leads to functionally diverse 'specialized ribosomes' is still a controversial topic. Here, we explore...
8.
9.
Papanicolaou M, Parker A, Yam M, Filipe E, Wu S, Chitty J, et al.
Nat Commun
. 2022 Aug;
13(1):4587.
PMID: 35933466
The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours including...
10.
Espadas G, Morales-Sanfrutos J, Medina R, Lucas M, Novoa E, Sabido E
J Chromatogr A
. 2022 Jan;
1665:462803.
PMID: 35042139
Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most...