Morgan L Shannon
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Explore the profile of Morgan L Shannon including associated specialties, affiliations and a list of published articles.
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9
Citations
184
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Recent Articles
1.
Shannon M, Heimlich J, Olson S, Debevec A, Copeland Z, Kishtagari A, et al.
Blood Adv
. 2024 Apr;
8(13):3453-3463.
PMID: 38608257
Clonal hematopoiesis (CH) is an age-associated phenomenon leading to an increased risk of both hematologic malignancy and nonmalignant organ dysfunction. Increasingly available genetic testing has made the incidental discovery of...
2.
Shannon M, Muhammad A, James N, Williams M, Breeyear J, Edwards T, et al.
Clin Transl Sci
. 2023 Jun;
16(9):1628-1638.
PMID: 37353859
Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary...
3.
Fame R, Kalugin P, Petrova B, Xu H, Soden P, Shipley F, et al.
Nat Commun
. 2023 Jun;
14(1):3720.
PMID: 37349305
Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we developed a platform to analyze...
4.
Cui J, Shipley F, Shannon M, Alturkistani O, Dani N, Webb M, et al.
Dev Cell
. 2020 Oct;
55(5):617-628.e6.
PMID: 33038331
The choroid plexus (ChP) regulates brain development by secreting instructive cues and providing a protective brain barrier. Here, we show that polyI:C-mediated maternal immune activation leads to an inflammatory response...
5.
Shipley F, Dani N, Xu H, Deister C, Cui J, Head J, et al.
Neuron
. 2020 Sep;
108(4):623-639.e10.
PMID: 32961128
The choroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop imaging tools to...
6.
Fame R, Shannon M, Chau K, Head J, Lehtinen M
Development
. 2019 Oct;
146(20).
PMID: 31575649
Massive, coordinated cellular changes accompany the transition of central nervous system (CNS) progenitors from forebrain neurectodermal cells to specified neuroepithelial cells. We have previously found that MYC regulates the changing...
7.
Lun M, Shannon M, Keles S, Reisli I, Luche N, Ryan D, et al.
Am J Pathol
. 2019 Sep;
189(12):2440-2449.
PMID: 31541646
Cells of the developing central nervous system are particularly susceptible to formation of double-stranded DNA breaks (DSBs) arising from physiological and/or environmental insults. Therefore, efficient repair of DSBs is especially...
8.
Chau K, Shannon M, Fame R, Fonseca E, Mullan H, Johnson M, et al.
Elife
. 2018 May;
7.
PMID: 29745900
Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at...
9.
Shannon M, Fame R, Chau K, Dani N, Calicchio M, Geleoc G, et al.
Am J Pathol
. 2018 Mar;
188(6):1334-1344.
PMID: 29545198
Choroid plexus tumors and ciliary body medulloepithelioma are predominantly pediatric neoplasms. Progress in understanding the pathogenesis of these tumors has been hindered by their rarity and lack of models that...