Michael J Holtzman
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Explore the profile of Michael J Holtzman including associated specialties, affiliations and a list of published articles.
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163
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8609
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Recent Articles
1.
Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, et al.
Cell Rep
. 2025 Mar;
44(3):115383.
PMID: 40057957
The choroid plexus is a major site for cerebrospinal fluid (CSF) production, characterized by a multiciliated epithelial monolayer that regulates CSF production. We demonstrate that defective choroid plexus ciliogenesis or...
2.
Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, et al.
bioRxiv
. 2025 Feb;
PMID: 39896593
Choroid plexus is a major site for cerebrospinal fluid (CSF) production, characterized by a multiciliated epithelial monolayer that regulates CSF production. We demonstrate that defective choroid plexus ciliogenesis or Intraflagellar...
3.
Yang A, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605457
Phospholipid scramblase 1 (PLSCR1) is an antiviral interferon-stimulated gene (ISG) that has several known anti-influenza functions such as interfering with viral nuclear import, regulating toll-like receptor (TLR) 9 and potentiating...
4.
Wu K, Zhang Y, Yin-DeClue H, Sun K, Mao D, Crouch E, et al.
medRxiv
. 2024 Sep;
PMID: 39252892
Epithelial injury calls for a regenerative response from a coordinated network of epithelial stem cells and immune cells. Defining this network is key to preserving the repair process for acute...
5.
Jiang H, Cui H, Chen M, Li F, Shen X, Guo C, et al.
Cell
. 2024 Sep;
187(21):5981-5997.e14.
PMID: 39243765
Sneezing and coughing are primary symptoms of many respiratory viral infections and allergies. It is generally assumed that sneezing and coughing involve common sensory receptors and molecular neurotransmission mechanisms. Here,...
6.
Zhang Y, Wu K, Mao D, Iberg C, Yin-DeClue H, Sun K, et al.
bioRxiv
. 2024 Sep;
PMID: 39229202
The stress kinase MAPK13 (aka p38δ-MAPK) is an attractive entry point for therapeutic intervention because it regulates the structural remodeling that can develop after epithelial barrier injury in the lung...
7.
Wu K, Zhang Y, Yin-DeClue H, Sun K, Mao D, Yang K, et al.
J Clin Invest
. 2024 Jul;
134(18).
PMID: 39052353
Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are...
8.
Wu K, Zhang Y, Mao D, Iberg C, Yin-DeClue H, Sun K, et al.
bioRxiv
. 2024 Jun;
PMID: 38895360
All living organisms are charged with repair after injury particularly at epithelial barrier sites, but in some cases this response leads instead to structural remodeling and long-term disease. Identifying the...
9.
Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation
Kelly M, Dietz C, Kasson S, Zhang Y, Holtzman M, Kim I
Biochem Biophys Res Commun
. 2024 May;
720:150101.
PMID: 38749191
Poly(ADP-ribose) polymerases (PARPs) are critical to regulating cellular activities, such as the response to DNA damage and cell death. PARPs catalyze a reversible post-translational modification (PTM) in the form of...
10.
Holtzman M, Zhang Y, Wu K, Romero A
Eur Respir Rev
. 2024 Feb;
33(171).
PMID: 38417971
Respiratory viral infections are a major public health problem, with much of their morbidity and mortality due to post-viral lung diseases that progress and persist after the active infection is...