Morgan E DeSantis
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Explore the profile of Morgan E DeSantis including associated specialties, affiliations and a list of published articles.
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28
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1171
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Recent Articles
1.
Gillies J, Little S, Siva A, Hancock W, DeSantis M
J Biol Chem
. 2025 Feb;
:108358.
PMID: 40021125
Cytoplasmic dynein-1 (dynein), the primary retrograde motor in most eukaryotes, supports the movement of hundreds of distinct cargos, each with specific trafficking requirements. To achieve this functional diversity, dynein must...
2.
Gillies J, Little S, Hancock W, DeSantis M
bioRxiv
. 2024 Oct;
PMID: 39416085
Cytoplasmic dynein-1 (dynein), the primary retrograde motor in most eukaryotes, supports the movement of hundreds of distinct cargos, each with specific trafficking requirements. To achieve this functional diversity, dynein must...
3.
Zang J, Gibson D, Zheng A, Shi W, Gillies J, Stein C, et al.
bioRxiv
. 2024 Jun;
PMID: 38915497
Cytoplasmic dynein-1 (dynein) is a microtubule-associated, minus end-directed motor that traffics hundreds of different cargos. Dynein must discriminate between cargos and traffic them at the appropriate time from the correct...
4.
Badieyan S, Lichon D, Andreas M, Gillies J, Peng W, Shi J, et al.
bioRxiv
. 2023 Sep;
PMID: 37693451
Viruses exploit host cytoskeletal elements and motor proteins for trafficking through the dense cytoplasm. Yet the molecular mechanism that describes how viruses connect to the motor machinery is unknown. Here,...
5.
Garrott S, Gillies J, Siva A, Little S, El Jbeily R, DeSantis M
J Biol Chem
. 2023 Apr;
299(6):104735.
PMID: 37086789
Dynein is the primary minus-end-directed microtubule motor protein. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the "activated dynein complex." The protein Lis1 aids...
6.
He S, Gillies J, Zang J, Cordoba-Beldad C, Yamamoto I, Fujiwara Y, et al.
Nat Commun
. 2023 Mar;
14(1):1715.
PMID: 36973253
Spindle formation in male meiosis relies on the canonical centrosome system, which is distinct from acentrosomal oocyte meiosis, but its specific regulatory mechanisms remain unknown. Herein, we report that DYNLRB2...
7.
Garrott S, DeSantis M
Trends Biochem Sci
. 2023 Feb;
48(4):315-316.
PMID: 36754682
In a recent study, Chaaban and Carter use cryo-electron microscopy (cryo-EM) and an innovative data-processing pipeline to determine the first high-resolution structure of the dynein-dynactin-BICDR1 complex assembled on microtubules. The...
8.
Garrott S, Gillies J, Siva A, Little S, Jbeily R, DeSantis M
bioRxiv
. 2023 Feb;
PMID: 36747695
Dynein is the primary minus-end-directed microtubule motor [1]. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the "activated dynein complex" [2, 3]. The protein...
9.
Reimer J, DeSantis M, Reck-Peterson S, Leschziner A
Elife
. 2023 Jan;
12.
PMID: 36692009
The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by...
10.
Agrawal R, Gillies J, Zang J, Zhang J, Garrott S, Shibuya H, et al.
Elife
. 2022 Jun;
11.
PMID: 35703493
Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate...