Molly E Hoke
Overview
Explore the profile of Molly E Hoke including associated specialties, affiliations and a list of published articles.
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5
Citations
82
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Recent Articles
1.
Alpers D, Lewis J, Hunt C, Freston J, Torres V, Li H, et al.
Am J Kidney Dis
. 2022 Oct;
81(3):281-293.e1.
PMID: 36191725
Rationale & Objective: Tolvaptan is associated with risk of drug-induced liver injury when used to treat autosomal dominant polycystic kidney disease (ADPKD). After this risk was described based on the...
2.
Zhou X, Davenport E, Ouyang J, Hoke M, Garbinsky D, Agarwal I, et al.
Kidney Int Rep
. 2022 May;
7(5):1037-1048.
PMID: 35570988
Introduction: In 1- and 3-year randomized trials, tolvaptan slowed kidney function decline in subjects with autosomal dominant polycystic kidney disease (ADPKD) at risk of rapid progression. The 3-year trial also...
3.
Torres V, Chapman A, Devuyst O, Gansevoort R, Perrone R, Lee J, et al.
Clin J Am Soc Nephrol
. 2020 Dec;
16(1):48-58.
PMID: 33376102
Background And Objectives: Tolvaptan slows kidney function decline in patients with autosomal dominant polycystic kidney disease (ADPKD) at risk of rapid progression. In the 3-year Tolvaptan Efficacy and Safety in...
4.
Mayer S, Kreft A, Harrison B, Abou-Gharbia M, Antane M, Aschmies S, et al.
J Med Chem
. 2008 Nov;
51(23):7348-51.
PMID: 19012391
SAR on HTS hits 1 and 2 led to the potent, Notch-1-sparing GSI 9, which lowered brain Abeta in Tg2576 mice at 100 mg/kg po. Converting the metabolically labile methyl...
5.
Hoke M, Brescia M, Bogaczyk S, DeShong P, King B, Crimmins M
J Org Chem
. 2002 Jan;
67(2):327-35.
PMID: 11798302
The regioselectivity of Pd-catalyzed malonate additions and arylations to cycloalkenyl esters can be predicted by completing a stereochemical analysis of the Pd-pi-allyl complex. The Pd-catalyzed malonate additions which have the...