Mojtaba Samoudi
Overview
Explore the profile of Mojtaba Samoudi including associated specialties, affiliations and a list of published articles.
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10
Citations
101
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Recent Articles
1.
Masson H, Samoudi M, Robinson C, Kuo C, Weiss L, Shams Ud Doha K, et al.
Metab Eng
. 2023 Dec;
81:273-285.
PMID: 38145748
Understanding protein secretion has considerable importance in biotechnology and important implications in a broad range of normal and pathological conditions including development, immunology, and tissue function. While great progress has...
2.
Samoudi M, Masson H, Kuo C, Robinson C, Lewis N
Curr Opin Chem Eng
. 2023 Jul;
32.
PMID: 37475722
Mammalian cells have been used widely as biopharmaceutical cell factories due to their ability to make complex biotherapeutic proteins with human-compatible modifications. However, their application for some products has been...
3.
Masson H, Samoudi M, Robinson C, Kuo C, Weiss L, Shams Ud Doha K, et al.
bioRxiv
. 2023 May;
PMID: 37205389
Understanding protein secretion has considerable importance in the biotechnology industry and important implications in a broad range of normal and pathological conditions including development, immunology, and tissue function. While great...
4.
Samoudi M, Kuo C, Robinson C, Shams-Ud-Doha K, Schinn S, Kol S, et al.
Biotechnol Bioeng
. 2020 Nov;
118(2):890-904.
PMID: 33169829
Despite their therapeutic potential, many protein drugs remain inaccessible to patients since they are difficult to secrete. Each recombinant protein has unique physicochemical properties and requires different machinery for proper...
5.
Lee J, Park J, Ha T, Samoudi M, Lewis N, Palsson B, et al.
ACS Synth Biol
. 2018 Nov;
7(12):2867-2878.
PMID: 30388888
Generation of recombinant Chinese hamster ovary (rCHO) cell lines is critical for the production of therapeutic proteins. However, the high degree of phenotypic heterogeneity among generated clones, referred to as...
6.
Rupp O, MacDonald M, Li S, Dhiman H, Polson S, Griep S, et al.
Biotechnol Bioeng
. 2018 Apr;
115(8):2087-2100.
PMID: 29704459
Accurate and complete genome sequences are essential in biotechnology to facilitate genome-based cell engineering efforts. The current genome assemblies for Cricetulus griseus, the Chinese hamster, are fragmented and replete with...
7.
Kuo C, Chiang A, Shamie I, Samoudi M, Gutierrez J, Lewis N
Curr Opin Biotechnol
. 2017 Dec;
51:64-69.
PMID: 29223005
To meet the ever-growing demand for effective, safe, and affordable protein therapeutics, decades of intense efforts have aimed to maximize the quantity and quality of recombinant proteins produced in CHO...
8.
Chiang A, Li S, Spahn P, Richelle A, Kuo C, Samoudi M, et al.
Curr Opin Struct Biol
. 2016 Sep;
40:104-111.
PMID: 27639240
Diverse glycans on proteins impact cell and organism physiology, along with drug activity. Since many protein-based biotherapeutics are glycosylated and these glycans have biological activity, there is a desire to...
9.
Samoudi M, Omid Yeganeh N, Shahbani Zahiri H, Shariati P, Hajhosseini R
Avicenna J Med Biotechnol
. 2015 Aug;
7(3):113-20.
PMID: 26306151
Background: Coenzyme Q 10 (CoQ 10 ) is an isoprenoid component used widely in nutraceutical industries. Farnesyl diphosphate synthase (FPPS) is a responsible enzyme for biosynthesis of farnesyl diphosphate (FPP),...
10.
Samoudi M, Tabandeh F, Minuchehr Z, Cohan R, Nouri Inanlou D, Khodabandeh M, et al.
J Mol Graph Model
. 2014 Dec;
56:31-42.
PMID: 25544388
Glycoengineering has been successfully used to improve the physicochemical and pharmaceutical properties of therapeutics. One aspect of glycoengineering is to introduce new N-linked glycosylation consensus sequences (Asn, X, Thr/Ser) into...