Mohit Chhabra
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Explore the profile of Mohit Chhabra including associated specialties, affiliations and a list of published articles.
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27
Citations
271
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Recent Articles
1.
Chhabra M, Shanthamurthy C, Kumar N, Mardhekar S, Vishweshwara S, Wimmer N, et al.
J Med Chem
. 2024 Jul;
67(14):11885-11916.
PMID: 38995734
Herein, we report the synthesis and biological evaluation of a novel series of heparinoid amphiphiles as inhibitors of heparanase and SARS-CoV-2. By employing a tailor-made synthetic strategy, a library of...
2.
Goel R, Shah S, Gupta S, Khullar T, Singh S, Chhabra M, et al.
Eye (Lond)
. 2023 May;
37(17):3682-3690.
PMID: 37221361
Purpose: To study the orbital perfusion parameters of ophthalmic artery (OA) and central retinal artery (CRA) in inactive TED and the changes following surgical decompression. Methods: Non-randomised clinical trial. 24...
3.
Lo M, Amarilla A, Lee J, Albornoz E, Modhiran N, Clark R, et al.
Clin Transl Immunology
. 2022 Aug;
11(8):e1413.
PMID: 35999893
Objectives: To determine whether SARS-CoV-2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect. Methods: SARS-CoV-2 was inoculated into a human lepirudin-anticoagulated...
4.
Guimond S, Mycroft-West C, Gandhi N, Tree J, Le T, Spalluto C, et al.
ACS Cent Sci
. 2022 Jun;
8(5):527-545.
PMID: 35647275
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic...
5.
Dipu T, Goel R, Arora R, Thakar M, Gautam A, Shah S, et al.
Indian J Ophthalmol
. 2022 May;
70(5):1780-1786.
PMID: 35502072
Purpose: To evaluate the retinal microvascular changes in patients, recovered from severe COVID-19 during the second wave of the pandemic in North India. Methods: In this observational cross-sectional study, 70...
6.
Chhabra M, Wilson J, Wu L, Davies G, Gandhi N, Ferro V
Chemistry
. 2022 Jan;
28(11):e202104222.
PMID: 34981584
Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently in clinical trials, is a potent inhibitor of heparanase. Heparanase is an endo-β-glucuronidase that degrades HS in the extracellular...
7.
Goel R, Arora R, Shah S, Chhabra M, Kumar J, Khurana N, et al.
Ophthalmic Plast Reconstr Surg
. 2021 Dec;
38(3):242-249.
PMID: 34919070
Purpose: To correlate the clinical, radiological, and histopathological features in Covid-associated Rhino-orbito-cerebral mucormycosis cases presenting with acute visual loss. Design: Cross-sectional study. Methods: Covid-associated Rhino-orbito-cerebral mucormycosis cases with unilateral visual...
8.
Chhabra M, Wimmer N, He Q, Ferro V
Bioconjug Chem
. 2021 Oct;
32(11):2420-2431.
PMID: 34652896
The heparan sulfate (HS) mimetic pixatimod (PG545) is a highly potent inhibitor of angiogenesis, tumor growth, and metastasis currently in clinical trials for cancer. PG545 has also demonstrated potent antiviral...
9.
Arora R, Goel R, Khanam S, Kumar S, Shah S, Singh S, et al.
Clin Ophthalmol
. 2021 Aug;
15:3505-3514.
PMID: 34429582
Purpose: To list the clinico-epidemiological profile and possible risk factors of COVID-19 associated rhino-orbital-cerebral mucormycosis (CA-ROCM) patients presenting to a COVID dedicated hospital during the second wave of COVID-19 in...
10.
Chhabra M, Doherty G, See N, Gandhi N, Ferro V
Chem Rec
. 2021 Jun;
21(11):3087-3101.
PMID: 34145723
Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate a vast array of biological...