Mohan Somasundaran
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Explore the profile of Mohan Somasundaran including associated specialties, affiliations and a list of published articles.
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43
Citations
4974
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Recent Articles
1.
Huang Q, Kim R, Song K, Grigorieff N, Munro J, Schiffer C, et al.
bioRxiv
. 2024 Oct;
PMID: 39463923
Influenza viruses are enveloped, negative sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80-90% of influenza glycoprotein and plays a role in host...
2.
Lim S, Guo Z, Liu P, McKay L, Storm N, Griffiths A, et al.
COVID
. 2023 Jun;
2(11):1551-1563.
PMID: 37274537
Coronavirus disease 2019 (COVID-19) has had devastating effects worldwide, with particularly high morbidity and mortality in outbreaks on residential care facilities. Amantadine, originally licensed as an antiviral agent for therapy...
3.
Hariharan V, Shin M, Chang C, OReilly D, Biscans A, Yamada K, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2219523120.
PMID: 36893269
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid development of pan-viral variant therapeutics. Oligonucleotide therapeutics...
4.
Chang C, Parsi K, Somasundaran M, Vanderleeden E, Liu P, Cruz J, et al.
Viruses
. 2022 Jul;
14(7).
PMID: 35891350
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, causing surges, breakthrough infections, and devastating losses-underscoring the importance of identifying SARS-CoV-2 antivirals. A simple, accessible human...
5.
Huang Q, Song K, Xu C, Bolon D, Wang J, Finberg R, et al.
Structure
. 2022 Mar;
30(5):777-786.e3.
PMID: 35290796
Influenza viruses pose severe public health threats globally. Influenza viruses are extensively pleomorphic, in shape, size, and organization of viral proteins. Analysis of influenza morphology and ultrastructure can help elucidate...
6.
Jiang L, Samant N, Liu P, Somasundaran M, Jensen J, Marasco W, et al.
J Virol
. 2022 Jan;
96(6):e0198221.
PMID: 35045267
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive mutations can rescue fitness defects and facilitate the segregation...
7.
Koupenova M, Corkrey H, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, et al.
Circ Res
. 2021 Jul;
129(6):631-646.
PMID: 34293929
[Figure: see text].
8.
Lockbaum G, Henes M, Talledge N, Rusere L, Kosovrasti K, Nalivaika E, et al.
ACS Chem Biol
. 2021 Feb;
16(3):529-538.
PMID: 33619959
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that can cause severe paralytic neurologic disease and immune disorders as well as cancer. An estimated 20 million people worldwide...
9.
Harshbarger W, Deming D, Lockbaum G, Attatippaholkun N, Kamkaew M, Hou S, et al.
Nat Commun
. 2021 Jan;
12(1):559.
PMID: 33495478
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report structural details for heterosubtypic recognition...
10.
Prachanronarong K, Canale A, Liu P, Somasundaran M, Hou S, Poh Y, et al.
J Virol
. 2018 Nov;
93(2).
PMID: 30381484
Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies (sBnAbs) targeting the influenza virus hemagglutinin (HA)...