Mohan Chen
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Explore the profile of Mohan Chen including associated specialties, affiliations and a list of published articles.
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46
Citations
231
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Recent Articles
1.
Lu Y, Li H, Chen M, Lin Y, Zhang X
J Transl Med
. 2025 Jan;
23(1):35.
PMID: 39789539
Background: The partial epithelial-mesenchymal transition (EMT) is emerging as a significant mechanism in diabetic nephropathy (DN). LOX is a copper amine oxidase conventionally thought to act by crosslinking collagen. However,...
2.
Liu J, Zhang X, Chen T, Zhang Y, Zhang D, Zhang L, et al.
J Chem Theory Comput
. 2024 Jun;
20(13):5717-5731.
PMID: 38898771
Rapid advancements in machine-learning methods have led to the emergence of machine-learning-based interatomic potentials as a new cutting-edge tool for simulating large systems with ab initio accuracy. Still, the community...
3.
Liu Y, Zhangding Z, Liu X, Gan T, Ai C, Wu J, et al.
Science
. 2024 Mar;
383(6688):1215-1222.
PMID: 38484065
DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To...
4.
Liu R, Liu Z, Chen M, Xing H, Zhang P, Zhang J
Chem Sci
. 2023 Dec;
15(1):134-145.
PMID: 38131089
Nucleocytoplasmic shuttling proteins (NSPs) have emerged as a promising class of therapeutic targets for many diseases. However, most NSPs-based therapies largely rely on small-molecule inhibitors with limited efficacy and off-target...
5.
Zhang W, Zhou L, Yan T, Chen M
J Phys Chem B
. 2023 Oct;
127(41):8926-8937.
PMID: 37812657
The stability of rare earth element (REE) complexes plays a crucial role in quantitatively assessing their hydrothermal migration and transformation. However, reliable data are lacking under high-temperature hydrothermal conditions, which...
6.
Chen Z, Chen M, Liu R, Fan H, Zhang J
Chem Commun (Camb)
. 2023 Sep;
59(77):11560-11563.
PMID: 37681438
By introducing a therapeutic nucleoside analogue tail to the parent Aptamer-PROTACs, a PROTAC-cocktail system (ApTCs-3X) was designed and evaluated. ApTCs-3X exhibited improved nuclease resistance and efficiently degraded target protein with...
7.
Liu R, Zheng D, Liang X, Ren X, Chen M, Li W
J Chem Phys
. 2023 Aug;
159(7).
PMID: 37602804
Kohn-Sham density functional theory (DFT) is nowadays widely used for electronic structure theory simulations, and the accuracy and efficiency of DFT rely on approximations of the exchange-correlation functional. By including...
8.
Liu R, Chen M
J Chem Theory Comput
. 2023 Aug;
19(16):5602-5608.
PMID: 37535904
The hydrogen-bond (H-bond) network of high-pressure water is investigated by neural-network-based molecular dynamics (MD) simulations with first-principles accuracy. The static structure factors (SSFs) of water at three densities, i.e., 1,...
9.
Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, et al.
Nat Genet
. 2023 Jul;
55(8):1347-1358.
PMID: 37500731
Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism underlying its role in tumorigenesis is unclear. Here, we found that depletion of RAD21, a core subunit of cohesin,...
10.
Liu R, Yun Y, Feng Z, Chen M, Zhang J
Anal Chem
. 2023 Jun;
95(27):10322-10329.
PMID: 37339384
The level of 25-hydroxyvitamin D [25(OH)VD3] in human blood is considered as the best indicator of vitamin D status, and its deficiency or excess can lead to various health problems....