Mohammad Zulkifli
Overview
Explore the profile of Mohammad Zulkifli including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
160
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0
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Recent Articles
1.
Zulkifli M, Maremanda K, Okonkwo A, Farid I, Gohil V
J Pharmacol Exp Ther
. 2025 Mar;
392(2):100048.
PMID: 40023603
Copper (Cu) is an essential cofactor for metalloenzymes such as cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial electron transport chain. Mutations that directly or indirectly prevent Cu...
2.
Singh K, Soukar J, Zulkifli M, Kersey A, Lokhande G, Ghosh S, et al.
Nat Commun
. 2024 Sep;
15(1):8136.
PMID: 39289340
Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and neurodegenerative disorders. Thus, boosting mitochondrial biogenesis has been proposed as a...
3.
Lee J, Gohil V, Heidari P, Seidel J, Zulkifli M, Wei Y, et al.
Stroke
. 2024 Apr;
55(5):1370-1380.
PMID: 38572656
Background: Mild chemical inhibition of mitochondrial respiration can confer resilience against a subsequent stroke or myocardial infarction, also known as preconditioning. However, the lack of chemicals that can safely inhibit...
4.
Zulkifli M, Okonkwo A, Gohil V
J Mol Biol
. 2023 Oct;
435(23):168317.
PMID: 37858707
Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that function as electron transfer proteins in diverse metabolic pathways. Mammalian mitochondria contain two ferredoxins, FDX1 and FDX2, which share a high...
5.
Zulkifli M, Spelbring A, Zhang Y, Soma S, Chen S, Li L, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(10):e2216722120.
PMID: 36848556
Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we currently do not understand the mechanism by which copper brought into cells...
6.
Garza N, Swaminathan A, Maremanda K, Zulkifli M, Gohil V
Trends Endocrinol Metab
. 2022 Nov;
34(1):21-33.
PMID: 36435678
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in diverse physiological processes, including mitochondrial energy generation. Copper enters cells through a dedicated copper transporter and...
7.
Garza N, Zulkifli M, Gohil V
J Biol Chem
. 2022 Jun;
298(7):102139.
PMID: 35714767
Copper (Cu) and iron (Fe) are redox-active metals that serve as cofactors for many essential cellular enzymes. Disruption in the intracellular homeostasis of these metals results in debilitating and frequently...
8.
Swaminathan A, Soma S, Vicary A, Zulkifli M, Kaur H, Gohil V
Genetics
. 2022 Jun;
221(4).
PMID: 35666203
Cytochrome c oxidase (CcO) is a multimeric copper-containing enzyme of the mitochondrial respiratory chain that powers cellular energy production. The two core subunits of cytochrome c oxidase, Cox1 and Cox2,...
9.
Ghosh S, Zulkifli M, Joshi A, Venkatesan M, Cristel A, Vishnu N, et al.
Hum Mol Genet
. 2021 Sep;
31(3):376-385.
PMID: 34494107
Calcium signaling via mitochondrial calcium uniporter (MCU) complex coordinates mitochondrial bioenergetics with cellular energy demands. Emerging studies show that the stability and activity of the pore-forming subunit of the complex,...
10.
Garza N, Griffin A, Zulkifli M, Qiu C, Kaplan C, Gohil V
J Biol Chem
. 2021 Mar;
296:100485.
PMID: 33662401
Copper is essential for the activity and stability of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Loss-of-function mutations in genes required for copper transport to...