Mohammad T Mazhab-Jafari
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Explore the profile of Mohammad T Mazhab-Jafari including associated specialties, affiliations and a list of published articles.
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32
Citations
690
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Recent Articles
1.
Mo Y, Keszei A, Kothari S, Liu H, Pan A, Kim P, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40068204
Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release, remains unclear. Here, we elucidate...
2.
Feng Y, Goncalves M, Jitkova Y, Keszei A, Yan Y, Sarathy C, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2422447122.
PMID: 39879245
ClpXP is a two-component mitochondrial matrix protease. The caseinolytic mitochondrial matrix peptidase chaperone subunit X (ClpX) recognizes and translocates protein substrates into the degradation chamber of the caseinolytic protease P...
3.
Ona Chuquimarca S, Beenstock J, Daou S, Porat J, Keszei A, Yin J, et al.
Nat Commun
. 2024 Dec;
15(1):10633.
PMID: 39639027
The enzyme complex KEOPS (Kinase, Endopeptidase and Other Proteins of Small size) installs the universally conserved and essential N-threonylcarbamoyl adenosine modification (tA) on ANN-decoding tRNAs in eukaryotes and in archaea....
4.
Pasini E, Baciu C, Angeli M, Arendt B, Pellegrina D, Reimand J, et al.
Int J Hepatol
. 2024 Dec;
2024:5560676.
PMID: 39624175
Background: Metabolic dysfunction-associated steatohepatitis (MASH) has become the leading cause of chronic liver disease, but there has been no approved pharmacotherapy to date. Methods: We used a network analysis approach...
5.
Samani E, Hasan S, Waas M, Keszei A, Xu X, Heydari M, et al.
Structure
. 2024 Nov;
33(1):51-61.e3.
PMID: 39615488
Studying native protein structures at near-atomic resolution in a crowded environment presents challenges. Consequently, understanding the structural intricacies of proteins within pathologically affected tissues often relies on mass spectrometry and...
6.
Nguyen D, Rath D, Devost D, Petrin D, Rizk R, Ji A, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(17):e2315018121.
PMID: 38625940
Heterotrimeric G proteins can be regulated by posttranslational modifications, including ubiquitylation. KCTD5, a pentameric substrate receptor protein consisting of an N-terminal BTB domain and a C-terminal domain, engages CUL3 to...
7.
Yin J, Keszei A, Houliston S, Filandr F, Beenstock J, Daou S, et al.
Structure
. 2024 Mar;
32(6):795-811.e6.
PMID: 38531363
GCN2 is a stress response kinase that phosphorylates the translation initiation factor eIF2α to inhibit general protein synthesis when activated by uncharged tRNA and stalled ribosomes. The presence of a...
8.
Samani E, Chen A, Lou J, Dai D, Keszei A, Tan G, et al.
Commun Biol
. 2024 Jan;
7(1):92.
PMID: 38216676
Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes. In fungi, FAS...
9.
Iyer K, Li S, Revie N, Lou J, Duncan D, Fallah S, et al.
Cell Chem Biol
. 2023 Jun;
30(7):795-810.e8.
PMID: 37369212
Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal, poses an increasing threat to human health. To identify antifungal compounds, we screened the RIKEN natural product depository...
10.
Hasan S, Lou J, Keszei A, Dai D, Mazhab-Jafari M
Nat Commun
. 2023 Jun;
14(1):3460.
PMID: 37308485
Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an important intracellular signaling molecule....