Mohammad Mairaj Siddiquei
Overview
Explore the profile of Mohammad Mairaj Siddiquei including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
625
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Recent Articles
1.
Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy
Abu El-Asrar A, Nawaz M, Allegaert E, Siddiquei M, Ahmad A, Gikandi P, et al.
Molecules
. 2022 Sep;
27(18).
PMID: 36144730
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular...
2.
Abu El-Asrar A, Ahmad A, Nawaz M, Siddiquei M, De Zutter A, Vanbrabant L, et al.
Front Physiol
. 2022 Jan;
12:807747.
PMID: 35082694
Endogenous tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) has powerful regulatory effects on inflammation and angiogenesis. In this study, we investigated the role of TIMP-3 in regulating inflammation in the diabetic...
3.
Alkharfy K, Ahmad A, Siddiquei M, Ghulam M, El-Asrar A
Curr Mol Pharmacol
. 2022 Jan;
16(2):188-196.
PMID: 35049444
Background: Diabetic retinopathy (DR) is a slow eye disease that affects the retina due to a long-standing uncontrolled diabetes mellitus. Hyperglycemia-induced oxidative stress can lead to neuronal damage leading to...
4.
De Zutter A, Crijns H, Berghmans N, Garcia-Caballero M, Vanbrabant L, Portner N, et al.
Cancers (Basel)
. 2021 Oct;
13(20).
PMID: 34680238
Growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF) are important angiogenesis-mediating factors. They exert their effects not only through their...
5.
Abu El-Asrar A, Nawaz M, Ahmad A, Siddiquei M, Allegaert E, Gikandi P, et al.
Invest Ophthalmol Vis Sci
. 2021 Jul;
62(9):32.
PMID: 34293080
Purpose: Inflammation, angiogenesis and fibrosis are pathological hallmarks of proliferative diabetic retinopathy (PDR). The CD146/sCD146 pathway displays proinflammatory and proangiogenic properties. We investigated the role of this pathway in the...
6.
Abu El-Asrar A, Nawaz M, Ahmad A, De Zutter A, Siddiquei M, Blanter M, et al.
Front Immunol
. 2021 Feb;
11:601639.
PMID: 33552057
The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation and angiogenesis. We investigated the involvement of these chemokine pathways and their processing metalloproteinases ADAM10 and ADAM17 in...
7.
Ahmad A, Nawaz M, Siddiquei M, Abu El-Asrar A
Mol Cell Biochem
. 2021 Jan;
476(5):2099-2109.
PMID: 33515385
NADPH oxidase (NOX) is a main producers of reactive oxygen species (ROS) that may contribute to the early pathogenesis of diabetic retinopathy (DR). ROS has harmful effects on endogenous neuro-survival...
8.
Abu El-Asrar A, Ahmad A, Siddiquei M, De Zutter A, Allegaert E, Gikandi P, et al.
Front Immunol
. 2019 Dec;
10:2752.
PMID: 31866994
The macrophage migration inhibitory factor (MIF)/CD74 signaling pathway is strongly implicated in inflammation and angiogenesis. We investigated the expression of MIF and its receptor CD74 in proliferative diabetic retinopathy (PDR)...
9.
Abu El-Asrar A, Ahmad A, Allegaert E, Siddiquei M, Gikandi P, De Hertogh G, et al.
Ocul Immunol Inflamm
. 2019 Aug;
28(4):575-588.
PMID: 31403827
Purpose: To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163 M2 macrophages in proliferative diabetic retinopathy (PDR). Methods: Vitreous samples from 29 PDR...
10.
Abu El-Asrar A, Ahmad A, Allegaert E, Siddiquei M, Alam K, Gikandi P, et al.
Acta Ophthalmol
. 2019 Jul;
98(1):e1-e12.
PMID: 31318490
Purpose: Galectin-1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin-1 may be involved in the pathogenesis of proliferative diabetic retinopathy (PDR). Methods: Vitreous samples from...