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Miwa Sasai

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Articles 69
Citations 2744
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Recent Articles
1.
Nakayama Y, Sasai M, Kuratani A, Okamoto M, Okuzaki D, Yamamoto K, et al.
iScience . 2025 Mar; 28(3):111975. PMID: 40060898
Alveolar macrophages (AMs) are essential for maintaining lung homeostasis. However, their roles in respiratory infections have been controversial because the methods of depleting them have often suffered from poor cell...
2.
Kuratani A, Okamoto M, Kishida K, Okuzaki D, Sasai M, Sakaguchi S, et al.
Science . 2024 Nov; 386(6724):eadn8608. PMID: 39571033
The tumor microenvironment (TME) contains a number of immune-suppressive cells such as T helper 1-polarized regulatory T cells (T1-T cells). However, little is known about the mechanism behind the abundant...
3.
Okamoto M, Kuratani A, Okuzaki D, Kamiyama N, Kobayashi T, Sasai M, et al.
Proc Natl Acad Sci U S A . 2024 Nov; 121(48):e2401692121. PMID: 39560646
Experimental autoimmune encephalomyelitis (EAE) is the most widely used rodent model for multiple sclerosis. Interferon-γ (IFN-γ) and regulatory T cells (Tregs) are individually well known to play beneficial roles in...
4.
Nakayama Y, Ihara F, Okuzaki D, Nishikawa Y, Sasai M, Yamamoto M
Parasitol Int . 2024 Nov; 105:102995. PMID: 39557359
One of the dense granule proteins named GRA15 in Toxoplasma gondii (T. gondii), is known to support an innate immune response in host through activation of NF-κB. However, little is...
5.
Okamoto M, Kuratani A, Okuzaki D, Kamiyama N, Kobayashi T, Sasai M, et al.
Front Immunol . 2024 Sep; 15:1440918. PMID: 39286257
Bleomycin (BLM) induces lung injury, leading to inflammation and pulmonary fibrosis. Regulatory T cells (Tregs) maintain self-tolerance and control host immune responses. However, little is known about their involvement in...
6.
Okano T, Ashida H, Komatsu N, Tsukasaki M, Iida T, Iwasawa M, et al.
Int J Oral Sci . 2024 Aug; 16(1):54. PMID: 39143049
Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism is poorly understood. Here,...
7.
Tachibana Y, Sasai M, Yamamoto M
mBio . 2024 Jul; 15(9):e0172824. PMID: 39082802
The research field to identify and characterize genes essential for virulence in has been dramatically advanced by a series of clustered regularly interspaced short palindromic repeats (CRISPR) screens. Although subcellular...
8.
Ihara F, Kyan H, Takashima Y, Ono F, Hayashi K, Matsuo T, et al.
Nat Commun . 2024 May; 15(1):4278. PMID: 38778039
Toxoplasma gondii is a global protozoan pathogen. Clonal lineages predominate in Europe, North America, Africa, and China, whereas highly recombinant parasites are endemic in South/Central America. Far East Asian T....
9.
Sakuma C, Shizukuishi S, Ogawa M, Honjo Y, Takeyama H, Guan J, et al.
Cell Rep . 2024 Apr; 43(5):114131. PMID: 38656870
Atg8 paralogs, consisting of LC3A/B/C and GBRP/GBRPL1/GATE16, function in canonical autophagy; however, their function is controversial because of functional redundancy. In innate immunity, xenophagy and non-canonical single membranous autophagy called...
10.
Maeda R, Seki N, Uwamino Y, Wakui M, Nakagama Y, Kido Y, et al.
Nat Commun . 2023 Dec; 14(1):8469. PMID: 38123556
Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum metabolome analysis of a total of...