Mitsuhiro Machitani
Overview
Explore the profile of Mitsuhiro Machitani including associated specialties, affiliations and a list of published articles.
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20
Citations
214
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Recent Articles
1.
Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita K, et al.
Nat Cell Biol
. 2024 May;
26(6):932-945.
PMID: 38806647
As aberrant accumulation of RNA-DNA hybrids (R-loops) causes DNA damage and genome instability, cells express regulators of R-loop structures. Here we report that RNA-dependent RNA polymerase (RdRP) activity of human...
2.
Machitani M, Takei J, Kaneko M, Ueki S, Ohashi H, Watashi K, et al.
Virol J
. 2022 Dec;
19(1):213.
PMID: 36496472
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic of coronavirus disease 19. Coronaviruses, including SARS-CoV-2, use RNA-dependent RNA polymerase (RdRP) for viral replication...
3.
Matsuda Y, Yamashita T, Ye J, Yasukawa M, Yamakawa K, Mukai Y, et al.
J Pathol
. 2022 Jan;
257(2):172-185.
PMID: 35094384
Recent evidence indicates that RNA-dependent RNA polymerase (RdRP) activity of human telomerase reverse transcriptase (hTERT) regulates expression of target genes and is directly involved in tumor formation in a telomere-independent...
4.
Machitani M, Yasukawa M, Nakashima J, Furuichi Y, Masutomi K
Cancer Sci
. 2020 Aug;
111(11):3976-3984.
PMID: 32805774
A recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising...
5.
The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response
Machitani M, Taniguchi I, McCloskey A, Suzuki T, Ohno M
RNA
. 2020 Aug;
26(11):1716-1725.
PMID: 32759388
PHAX (phosphorylated adaptor for RNA export) promotes nuclear export of short transcripts of RNA polymerase II such as spliceosomal U snRNA precursors, as well as intranuclear transport of small nucleolar...
6.
Yasukawa M, Ando Y, Yamashita T, Matsuda Y, Shoji S, Morioka M, et al.
Nat Commun
. 2020 Mar;
11(1):1557.
PMID: 32214089
The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis...
7.
Machitani M, Taniguchi I, Ohno M
Mol Cell Biol
. 2019 Dec;
40(4).
PMID: 31818879
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA that functions as an essential framework of subnuclear paraspeckle bodies. Of the two isoforms (NEAT1_1 and NEAT1_2) produced by...
8.
Tomita K, Sakurai F, Iizuka S, Hemmi M, Wakabayashi K, Machitani M, et al.
Sci Rep
. 2018 Aug;
8(1):12315.
PMID: 30120324
Pre-existing anti-adenovirus (Ad) neutralizing antibodies (AdNAbs) are a major barrier in clinical gene therapy using Ad vectors and oncolytic Ads; however, it has not been fully elucidated which Ad capsid...
9.
Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Kato N, et al.
Mol Ther Oncolytics
. 2017 Dec;
7:76-85.
PMID: 29202008
Telomerase-specific replication-competent adenoviruses (Ads), i.e., TRADs, which possess an E1 gene expression cassette driven by the human telomerase reverse transcriptase promoter, are promising agents for cancer treatment. However, even though...
10.
Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
J Virol
. 2017 Mar;
91(12).
PMID: 28356525
Recent studies have reported that host microRNAs (miRNAs) regulate infections by several types of viruses via various mechanisms and that inhibition of the miRNA processing factors enhances or prevents viral...