Mitsuhiko Osaki
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Explore the profile of Mitsuhiko Osaki including associated specialties, affiliations and a list of published articles.
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128
Citations
2466
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Recent Articles
1.
Seong H, Izutsu R, Osaki M, Okada F
Genes Environ
. 2025 Feb;
47(1):4.
PMID: 40011962
Almost 70 years have passed since the molecular mechanism of carcinogenesis was hypothesized to involve multiple gene mutations. More than 1,000 cancer-related genes, including oncogenes and tumor suppressor genes, accelerate...
2.
Uno N, Miyamoto H, Yamazaki K, Egawa M, Kobayashi H, Kazuki K, et al.
Mol Ther Nucleic Acids
. 2024 Dec;
35(4):102382.
PMID: 39634136
Microcell-mediated chromosome transfer (MMCT) is anticipated as a unique strategy to manipulate numbers of chromosomes, including the generation of hyperaneuploidy syndrome models with human induced pluripotent stem cells (hiPSCs). Mouse...
3.
Egawa M, Uno N, Komazaki R, Ohkame Y, Yamazaki K, Yoshimatsu C, et al.
Genes Cells
. 2024 Nov;
30(1):e13184.
PMID: 39581190
Missing an entire chromosome or chromosome arm in normal diploid cells has a deleterious impact on cell viability, which may contribute to the development of specific birth defects. Nevertheless, the...
4.
Seong H, Kanda Y, Izutsu R, Jehung J, Hamada J, Osaki M, et al.
Sci Rep
. 2024 Nov;
14(1):28183.
PMID: 39548119
AMIGO2 adheres to liver endothelium and induces liver metastasis. We revealed that genetically altering AMIGO2 expression in tumor cells affects their liver metastatic potential, depending on the AMIGO2 expression level....
5.
Izutsu R, Osaki M, Seong H, Ogata S, Sato R, Hamada J, et al.
Cancer Gene Ther
. 2024 Oct;
31(12):1786-1795.
PMID: 39379686
In our previous studies, we identified amphoterin-inducible gene and open reading frame 2 (AMIGO2) as a driver gene for liver metastasis and found that AMIGO2 expression in cancer cells worsens...
6.
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Komatsu H, et al.
Int J Clin Oncol
. 2024 May;
29(9):1354-1363.
PMID: 38811439
Background: Amphoterin-induced gene and open reading frame 2 (AMIGO2) have been reported to be related to the prognosis of colorectal, gastric, and cervical cancer. However, their association with ovarian cancer...
7.
Makinoya M, Miyatani K, Matsumi Y, Sakano Y, Shimizu S, Shishido Y, et al.
Sci Rep
. 2024 May;
14(1):10075.
PMID: 38698201
Intraperitoneal (IP) chemotherapy with paclitaxel (PTX) for gastric cancer (GC) with peritoneal metastasis (PM) is considered a promising treatment approach, however, there are no useful biomarkers to predict the efficacy...
8.
Ikebuchi A, Osaki M, Wada I, Nagata H, Nagira K, Azuma Y, et al.
J Gynecol Obstet Hum Reprod
. 2024 Feb;
53(3):102741.
PMID: 38364688
No abstract available.
9.
Ikebuchi A, Osaki M, Wada I, Nagata H, Nagira K, Azuma Y, et al.
J Gynecol Obstet Hum Reprod
. 2023 Aug;
52(9):102645.
PMID: 37597576
Objective: Adenomyosis is a gynecologic disorder characterized by symptoms of dysmenorrhea, abnormal uterine bleeding, and infertility. This study aimed to analyze the expression profiles of key inflammatory cytokines in the...
10.
Iida Y, Osaki M, Sato S, Izutsu R, Seong H, Okawa M, et al.
Mol Clin Oncol
. 2023 Jun;
19(1):56.
PMID: 37323247
Patients with recurrent cervical cancer have limited treatment options and are often considered to be incurable. Since the expression of amphoterin-induced gene and open reading frame 2 (AMIGO2) in clinical...