Mitchell J Frederick
Overview
Explore the profile of Mitchell J Frederick including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
53
Citations
4445
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Hsu T, Asmussen J, Koire A, Choi B, Gadhikar M, Huh E, et al.
Genome Res
. 2022 Mar;
32(5):916-929.
PMID: 35301263
Genetic variants drive the evolution of traits and diseases. We previously modeled these variants as small displacements in fitness landscapes and estimated their functional impact by differentiating the evolutionary relationship...
12.
Wilde D, Castro P, Bera K, Lai S, Madabhushi A, Corredor G, et al.
Mod Pathol
. 2022 Feb;
35(8):1045-1054.
PMID: 35184149
Oropharyngeal squamous cell carcinoma (OPSCC), largely fueled by the human papillomavirus (HPV), has a complex biological and immunologic phenotype. Although HPV/p16 status can be used to stratify OPSCC patients as...
13.
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, et al.
Nat Commun
. 2021 Nov;
12(1):6340.
PMID: 34732714
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally...
14.
Spiotto M, Taniguchi C, Klopp A, Colbert L, Lin S, Wang L, et al.
Semin Radiat Oncol
. 2021 Aug;
31(4):274-285.
PMID: 34455983
In multiple anatomic sites, patients with cancers associated with the Human Papillomavirus (HPV) experience better locoregional control and overall survival after radiotherapy and/or chemoradiotherapy than patients with HPV-negative cancers. These...
15.
Lindemann A, Patel A, Tang L, Tanaka N, Gleber-Netto F, Bartels M, et al.
Mol Cancer Ther
. 2021 May;
20(7):1257-1269.
PMID: 33947685
Despite advances in surgery, chemotherapy, and radiation, there are limited treatment options for advanced head and neck squamous cell carcinoma (HNSCC) and survival remains very poor. Therefore, effective therapies are...
16.
Shah P, Huang C, Li Q, Kazi S, Byers L, Wang J, et al.
Cells
. 2020 Dec;
9(12).
PMID: 33322834
Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated...
17.
Molkentine J, Molkentine D, Bridges K, Xie T, Yang L, Sheth A, et al.
Int J Radiat Biol
. 2020 Feb;
97(8):1121-1128.
PMID: 32073931
Purpose: Head and neck cancers (HNSCC) are routinely treated with radiotherapy; however, normal tissue toxicity remains a concern. Therefore, it is important to validate treatment modalities combining molecularly targeted agents...
18.
Sambandam V, Frederick M, Shen L, Tong P, Rao X, Peng S, et al.
Clin Cancer Res
. 2019 Feb;
25(11):3329-3340.
PMID: 30770351
Purpose: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including , but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway...
19.
Gleber-Netto F, Rao X, Guo T, Xi Y, Gao M, Shen L, et al.
JCI Insight
. 2019 Jan;
4(1).
PMID: 30626753
Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing dramatically. Although long-term survival rates for these patients are high, they often suffer from permanent radiotherapy-related morbidity. This has...
20.
Sanchez-Vega F, Mina M, Armenia J, Chatila W, Luna A, La K, et al.
Cell
. 2018 Apr;
173(2):321-337.e10.
PMID: 29625050
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ...