Mitchell E Granade
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Explore the profile of Mitchell E Granade including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
162
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Recent Articles
1.
Granade M, Hargett S, Lank D, Lemke M, Luse M, Isakson B, et al.
Mol Metab
. 2022 Jul;
63:101543.
PMID: 35811051
Objective: Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important...
2.
Granade M, Manigat L, Lemke M, Purow B, Harris T
Biochem Pharmacol
. 2022 Jan;
197:114908.
PMID: 34999054
The diacylglycerol kinase (DGK) family of lipid enzymes catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Both DAG and PA are lipid signaling molecules that are of notable...
3.
Merta H, Carrasquillo Rodriguez J, Anjur-Dietrich M, Vitale T, Granade M, Harris T, et al.
Dev Cell
. 2021 Dec;
56(24):3364-3379.e10.
PMID: 34852214
Failure to reorganize the endoplasmic reticulum (ER) in mitosis results in chromosome missegregation. Here, we show that accurate chromosome segregation in human cells requires cell cycle-regulated ER membrane production. Excess...
4.
Manigat L, Granade M, Taori S, Miller C, Vass L, Zhong X, et al.
Front Immunol
. 2021 Nov;
12:722469.
PMID: 34804012
The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs...
5.
Huang T, Hosseinibarkooie S, Borne A, Granade M, Brulet J, Harris T, et al.
Chem Sci
. 2021 Jun;
12(9):3295-3307.
PMID: 34164099
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of...
6.
Martinez B, Hoyle R, Yeudall S, Granade M, Harris T, Castle J, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009192.
PMID: 33227003
During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AMPs)...
7.
Bottermann K, Granade M, Oenarto V, Fischer J, Harris T
J Cardiovasc Pharmacol Ther
. 2020 Nov;
26(3):289-297.
PMID: 33150796
The pathological role of adipose derived fatty acids following myocardial infarction has long been hypothesized. However, most methods for reducing adipocyte lipolysis have significant non-adipose effects. Atglistatin, a direct inhibitor...
8.
Raje V, Ahern K, Martinez B, Howell N, Oenarto V, Granade M, et al.
Sci Rep
. 2020 Oct;
10(1):18166.
PMID: 33097799
Stress hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major trauma, burns, or hemorrhagic shock (HS). In response to injury, the neuroendocrine system increases secretion...
9.
Ware T, Franks C, Granade M, Zhang M, Kim K, Park K, et al.
Nat Chem Biol
. 2020 Jan;
16(2):170-178.
PMID: 31932721
C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol...
10.
Hennessy M, Granade M, Hassaninasab A, Wang D, Kwiatek J, Han G, et al.
J Biol Chem
. 2019 Jan;
294(7):2365-2374.
PMID: 30617183
The mammalian lipin 1 phosphatidate phosphatase is a key regulatory enzyme in lipid metabolism. By catalyzing phosphatidate dephosphorylation, which produces diacylglycerol, the enzyme plays a major role in the synthesis...