Mitchell A Hamman
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Explore the profile of Mitchell A Hamman including associated specialties, affiliations and a list of published articles.
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10
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411
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Recent Articles
1.
Quinney S, Malireddy S, Vuppalanchi R, Hamman M, Chalasani N, Gorski J, et al.
Eur J Clin Pharmacol
. 2012 Jul;
69(3):439-48.
PMID: 22777148
Aims: To determine the extent and time-course of hepatic and intestinal cytochrome P450 3A (CYP3A) inactivation due to the mechanism-based inhibitor clarithromycin. Methods: Intestinal and hepatic CYP3A inhibition was examined...
2.
Quinney S, Galinsky R, Jiyamapa-Serna V, Chen Y, Hamman M, Hall S, et al.
Drug Metab Dispos
. 2008 Mar;
36(6):1097-101.
PMID: 18339815
Itraconazole (ITZ) is a substrate of CYP3A and both ITZ and hydroxyitraconazole (OH-ITZ), a major metabolite formed by CYP3A, are potent inhibitors of CYP3A. The concentration- and time-dependent changes in...
3.
Lemma G, Wang Z, Hamman M, Zaheer N, Gorski J, Hall S
Clin Pharmacol Ther
. 2006 Mar;
79(3):218-30.
PMID: 16513446
Background: Verapamil has the capability to inhibit and induce cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp), but the relative extent and time course of these events in vivo are unclear....
4.
Borges S, Li L, Hamman M, Jones D, Hall S, Gorski J
Drug Metab Dispos
. 2005 Apr;
33(7):1052-5.
PMID: 15821042
Dextromethorphan urinary metabolic ratio is widely used to determine the CYP2D6 phenotype, but its utility to reflect subtle differences in catalytic activity is unclear. We evaluated the capability of dextromethorphan...
5.
Pinto A, Wang Y, Chalasani N, Skaar T, Kolwankar D, Gorski J, et al.
Clin Pharmacol Ther
. 2005 Mar;
77(3):178-88.
PMID: 15735612
Background: Clarithromycin increases both hepatic and intestinal availability of the selective cytochrome P450 (CYP) 3A probe midazolam. This study was designed to identify determinants of variability in the extent of...
6.
Gorski J, Huang S, Pinto A, Hamman M, Hilligoss J, Zaheer N, et al.
Clin Pharmacol Ther
. 2004 Jan;
75(1):89-100.
PMID: 14749695
Background: Echinacea is a widely available over-the-counter herbal remedy. Tinctures of echinacea have been shown to inhibit cytochrome P450 (CYP) in vitro. The effect of echinacea (Echinacea purpurea root) on...
7.
Hall S, Wang Z, Huang S, Hamman M, Vasavada N, Adigun A, et al.
Clin Pharmacol Ther
. 2003 Dec;
74(6):525-35.
PMID: 14663455
Objectives: The popular herbal remedy St John's wort is an inducer of cytochrome P450 (CYP) 3A enzymes and may reduce the efficacy of oral contraceptives. Therefore we evaluated the effect...
8.
Gorski J, Vannaprasaht S, Hamman M, Ambrosius W, Bruce M, Haehner-Daniels B, et al.
Clin Pharmacol Ther
. 2003 Sep;
74(3):275-87.
PMID: 12966371
Background: The relative susceptibility of intestinal and hepatic cytochrome P450 (CYP) 3A to induction by rifampin (INN, rifampicin), as a function of age and sex, was investigated with the CYP3A...
9.
Williams J, Ring B, Cantrell V, Jones D, Eckstein J, Ruterbories K, et al.
Drug Metab Dispos
. 2002 Jul;
30(8):883-91.
PMID: 12124305
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent evidence indicates that CYP3A5 contributes more...
10.
Wang Z, Hamman M, Huang S, Lesko L, Hall S
Clin Pharmacol Ther
. 2002 Jun;
71(6):414-20.
PMID: 12087344
Background: St John's wort is a popular over-the-counter dietary supplement and herbal remedy that has been implicated in drug interactions with several substrates of P-glycoprotein. The effect of St John's...