Mirja Harms
Overview
Explore the profile of Mirja Harms including associated specialties, affiliations and a list of published articles.
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28
Citations
346
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Recent Articles
1.
Khunti N, Kumar M, Datta M, Harelimana J, Harms M, Albers D, et al.
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076664
CD19 and CXCR4 are pivotal regulators of B-cell activation and migration, respectively. Specifically, CXCR4 signaling critically influences the dissemination of various malignant B cells through constitutive activation and aberrant expression....
2.
Gaonkar R, Bailly T, Millul J, Mansi R, Harms M, Munch J, et al.
ChemMedChem
. 2025 Jan;
e202400773.
PMID: 39782735
The C-X-C chemokine receptor 4 (CXCR4) is highly upregulated in most cancers, making it an ideal target for delivering radiation therapy to tumors. We previously demonstrated the feasibility of targeting...
3.
Freisem D, Rodriguez-Alfonso A, Lawrenz J, Zhou Z, Monecke T, Preising N, et al.
Cell Mol Life Sci
. 2024 Sep;
81(1):409.
PMID: 39289189
Autophagy is an evolutionarily ancient catabolic pathway and has recently emerged as an integral part of the innate immune system. While the core machinery of autophagy is well defined, the...
4.
Pohl J, Litz A, El Ayoubi O, Rodriguez-Alfonso A, Standker L, Harms M, et al.
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125877
Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph ALL) is characterized by reciprocal chromosomal translocation between chromosome 9 and 22, leading to the expression of constitutively active oncogenic BCR-ABL1 fusion protein. CXC chemokine...
5.
Harms M, Haase A, Rodriguez-Alfonso A, Loffler J, Almeida-Hernandez Y, Ruiz-Blanco Y, et al.
J Control Release
. 2024 Jul;
373:583-598.
PMID: 39047872
Dysregulation of the CXCL12/CXCR4 axis is implicated in autoimmune, inflammatory, and oncogenic diseases, positioning CXCR4 as a pivotal therapeutic target. We evaluated optimized variants of the specific endogenous CXCR4 antagonist,...
6.
Harms M, Hansson R, Gilg A, Almeida-Hernandez Y, Loffler J, Rodriguez-Alfonso A, et al.
J Med Chem
. 2023 Nov;
66(22):15189-15204.
PMID: 37940118
EPI-X4, a natural peptide CXCR4 antagonist, shows potential for treating inflammation and cancer, but its short plasma stability limits its clinical application. We aimed to improve the plasma stability of...
7.
Peptide Bispecifics Inhibiting HIV-1 Infection by an Orthogonal Chemical and Supramolecular Strategy
Schauenburg D, Zech F, Heck A, von Maltitz P, Harms M, Fuhrer S, et al.
Bioconjug Chem
. 2023 Sep;
34(9):1645-1652.
PMID: 37665137
Viral infections pose a significant threat to human health, and effective antiviral strategies are urgently needed. Antiviral peptides have emerged as a promising class of therapeutic agents due to their...
8.
Harms M, Smith N, Han M, Gross R, von Maltitz P, Sturzel C, et al.
Sci Adv
. 2023 Jul;
9(27):eadf8251.
PMID: 37406129
Semen is an important vector for sexual HIV-1 transmission. Although CXCR4-tropic (X4) HIV-1 may be present in semen, almost exclusively CCR5-tropic (R5) HIV-1 causes systemic infection after sexual intercourse. To...
9.
Gaonkar R, Schmidt Y, Mansi R, Almeida-Hernandez Y, Sanchez-Garcia E, Harms M, et al.
J Med Chem
. 2023 Jun;
66(13):8484-8497.
PMID: 37328158
The peptide fragment of human serum albumin that was identified as an inhibitor of C-X-C motif chemokine receptor 4 (CXCR4), termed EPI-X4, was investigated as a scaffold for the development...
10.
Rodriguez-Alfonso A, Heck A, Ruiz-Blanco Y, Gilg A, Standker L, Kuan S, et al.
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499357
Advanced derivatives of the ndogenous eptide nhibitor of CCR (EPI-X4) have shown therapeutic efficacy upon topical administration in animal models of asthma and dermatitis. Here, we studied the plasma stability...