Miriam Pinilla
Overview
Explore the profile of Miriam Pinilla including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
136
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Recent Articles
1.
Schachter J, Guijarro A, Angosto-Bazarra D, Pinilla M, Hurtado-Navarro L, Meunier E, et al.
Cell Rep
. 2025 Feb;
44(2):115233.
PMID: 40010300
Pyroptosis is a lytic cell death triggered by the cleavage of gasdermin (GSDM) proteins and subsequent pore formation by the N-terminal domain oligomerization in the plasma membrane. GSDMD is cleaved...
2.
Gorse L, Plessis L, Wearne S, Paradis M, Pinilla M, Chua R, et al.
EMBO Mol Med
. 2025 Feb;
17(3):535-562.
PMID: 39948420
In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the...
3.
Pinilla M, Gorse L, Meunier E
Med Sci (Paris)
. 2025 Jan;
41(1):12-15.
PMID: 39887090
No abstract available.
4.
Sanchez-Villalobos M, Campos Banos E, Martinez-Balsalobre E, Navarro-Ramirez V, Videla M, Pinilla M, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519257
Congenital anemias include a broad range of disorders marked by inherent abnormalities in red blood cells. These abnormalities include enzymatic, membrane, and congenital defects in erythropoiesis, as well as hemoglobinopathies...
5.
Rozario P, Pinilla M, Gorse L, Vind A, Robinson K, Toh G, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(2):e2309579121.
PMID: 38175865
Nigericin, an ionophore derived from , is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome...
6.
Pinilla M, Mazars R, Verge R, Gorse L, Paradis M, Suire B, et al.
J Exp Med
. 2023 Aug;
220(10).
PMID: 37642996
Human airway and corneal epithelial cells, which are critically altered during chronic infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome sensor NLRP1. Here, together with a companion study, we...
7.
Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa
Santoni K, Pericat D, Gorse L, Buyck J, Pinilla M, Prouvensier L, et al.
PLoS Pathog
. 2022 Jul;
18(7):e1010305.
PMID: 35849616
Multiple regulated neutrophil cell death programs contribute to host defense against infections. However, despite expressing all necessary inflammasome components, neutrophils are thought to be generally defective in Caspase-1-dependent pyroptosis. By...
8.
Planes R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, et al.
Mol Cell
. 2022 May;
82(13):2385-2400.e9.
PMID: 35594856
Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes, proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial cells express inflammasome-forming sensors and constitute the primary entry door of SARS-CoV-2....
9.
Bagayoko S, Leon-Icaza S, Pinilla M, Hessel A, Santoni K, Pericat D, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009927.
PMID: 34516571
Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. Pseudomonas aeruginosa expresses a phospholipase, ExoU that triggers pathological host...
10.
Eren E, Planes R, Bagayoko S, Bordignon P, Chaoui K, Hessel A, et al.
EMBO Rep
. 2020 Oct;
21(11):e50829.
PMID: 33124769
Inflammatory caspase-11 (rodent) and caspases-4/5 (humans) detect the Gram-negative bacterial component LPS within the host cell cytosol, promoting activation of the non-canonical inflammasome. Although non-canonical inflammasome-induced pyroptosis and IL-1-related cytokine...