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Minrong Ai

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Articles 21
Citations 1400
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Recent Articles
1.
Sloop K, Cox A, Wainscott D, White A, Droz B, Stutsman C, et al.
Sci Transl Med . 2024 Dec; 16(778):eadp5765. PMID: 39693407
Orally bioavailable, synthetic nonpeptide agonists (NPAs) of the glucagon-like peptide-1 receptor (GLP-1R) may offer an effective, scalable pharmacotherapy to address the metabolic disease epidemic. One of the first molecules in...
2.
Borner T, Reiner B, Crist R, Furst C, Doebley S, Halas J, et al.
Mol Metab . 2023 May; 73:101743. PMID: 37245848
Objective: Nausea and vomiting remain life-threatening obstacles to successful treatment of chronic diseases, despite a cadre of available antiemetic medications. Our inability to effectively control chemotherapy-induced nausea and vomiting (CINV)...
3.
Samms R, Cosgrove R, Snider B, Furber E, Droz B, Briere D, et al.
Diabetes . 2022 May; 71(7):1410-1423. PMID: 35499381
The induction of nausea and emesis is a major barrier to maximizing the weight loss profile of obesity medications, and therefore, identifying mechanisms that improve tolerability could result in added...
4.
Costa A, Ai M, Nunn N, Culotta I, Hunter J, Boutagouga Boudjadja M, et al.
Mol Metab . 2021 Nov; 55:101407. PMID: 34844019
Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We...
5.
Borner T, Geisler C, Fortin S, Cosgrove R, Alsina-Fernandez J, Dogra M, et al.
Diabetes . 2021 Aug; 70(11):2545-2553. PMID: 34380697
Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 therapeutics are limited by adverse side...
6.
Snider B, Geiser A, Yu X, Beebe E, Willency J, Qing K, et al.
J Endocr Soc . 2019 Jul; 3(7):1423-1444. PMID: 31286109
Oxytocin (OXT) has been shown to suppress appetite, induce weight loss, and improve glycemic control and lipid metabolism in several species, including humans, monkeys, and rodents. However, OXT's short half-life...
7.
Bae H, Chen S, Roche J, Ai M, Wu C, DiAntonio A, et al.
eNeuro . 2016 Mar; 3(2). PMID: 27022630
Synaptic signaling involves the release of neurotransmitter from presynaptic active zones (AZs). Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). At the...
8.
Ai M, Mills H, Kanai M, Lai J, Deng J, Schreiter E, et al.
PLoS One . 2015 Sep; 10(9):e0138127. PMID: 26382605
Genetically encoded calcium indicators (GECIs) permit imaging intracellular calcium transients. Among GECIs, the GFP-based GCaMPs are the most widely used because of their high sensitivity and rapid response to changes...
9.
Ai M, Cui Y, Sy M, Lee D, Zhang L, Larson K, et al.
PLoS One . 2015 Feb; 10(2):e0116237. PMID: 25642942
Lubricin, encoded by the gene PRG4, is the principal lubricant in articulating joints. We immunized mice genetically deficient for lubricin (Prg4-/-) with purified human lubricin, and generated several mAbs. We...
10.
Ai M, Blais S, Park J, Min S, Neubert T, Suh G
J Neurosci . 2013 Jun; 33(26):10741-9. PMID: 23804096
Drosophila olfactory sensory neurons express either odorant receptors or ionotropic glutamate receptors (IRs). The sensory neurons that express IR64a, a member of the IR family, send axonal projections to either...