Minna Groenning
Overview
Explore the profile of Minna Groenning including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
23
Citations
550
Followers
0
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Recent Articles
1.
Saggu M, Bou-Assaf G, Bucher R, Budyak I, Buecheler J, Cao S, et al.
J Pharm Sci
. 2024 Jan;
113(5):1401-1414.
PMID: 38220088
Silicone oil is a commonly used lubricant in pre-filled syringes (PFSs) and can migrate over time into solution in the form of silicone oil particles (SiOPs). The presence of these...
2.
Thorlaksen C, Schultz H, Gammelgaard S, Jiskoot W, Hatzakis N, Nielsen F, et al.
Int J Pharm
. 2022 Dec;
631:122490.
PMID: 36521637
The immunogenicity risk of therapeutic protein aggregates has been extensively investigated over the past decades. While it is established that not all aggregates are equally immunogenic, the specific aggregate characteristics,...
3.
Thorlaksen C, Neergaard M, Groenning M, Fodera V
Methods Mol Biol
. 2022 Oct;
2551:297-309.
PMID: 36310211
Inducing protein aggregation in vitro under various formulation and stress conditions may lead to an increased understanding of the different association routes a protein can undergo. However, a range of...
4.
Thorlaksen C, Stanciu A, Neergaard M, Jiskoot W, Groenning M, Fodera V
Eur J Pharm Biopharm
. 2022 Sep;
179:166-172.
PMID: 36087880
Insulin is a biotherapeutic protein, which, depending on environmental conditions such as pH, has been shown to form a large variety of aggregates with different structures and morphologies. This work...
5.
Thorlaksen C, Stanciu A, Neergaard M, Hatzakis N, Fodera V, Groenning M
Eur J Pharm Biopharm
. 2022 Sep;
179:147-155.
PMID: 36058445
Protein aggregates are often varying extensively in their morphological characteristics, which may lead to various biological outcomes, such as increased immunogenicity risk. However, isolation of aggregates with a specific morphology...
6.
Schack M, Dahl K, Rades T, Groenning M, Carpenter J
J Pharm Sci
. 2019 Apr;
108(9):2871-2879.
PMID: 31026447
Protein fibrils are of great interest due to their involvement in several pathologies and their roles in the degradation of many therapeutic protein products. Fibrils share highly similar secondary structural...
7.
Schack M, Horn Moller E, Friderichsen A, Carpenter J, Rades T, Groenning M
J Pharm Sci
. 2019 Feb;
108(3):1117-1129.
PMID: 30773199
The analysis of subvisible particles is currently challenging but pivotal to the understanding and control of the quality of protein therapeutics. While a range of characterization methods is available for...
8.
Schack M, Horn Moller E, Carpenter J, Rades T, Groenning M
J Pharm Sci
. 2018 Mar;
107(7):1842-1851.
PMID: 29574228
Regulatory authorities and scientific communities are increasingly attentive to the known and universal presence of small particulates in biological drug products. The underlying concern is that these particulates may cause...
9.
Frankaer C, Sonderby P, Bang M, Mateiu R, Groenning M, Bukrinski J, et al.
J Struct Biol
. 2017 May;
199(1):27-38.
PMID: 28527712
Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer's disease, diabetes mellitus type 2, or Parkinson's disease. The influence of metal...
10.
Herranz-Trillo F, Groenning M, van Maarschalkerweerd A, Tauler R, Vestergaard B, Bernado P
Structure
. 2016 Nov;
25(1):5-15.
PMID: 27889205
Formation of amyloids is the hallmark of several neurodegenerative pathologies. Structural investigation of these complex transformation processes poses significant experimental challenges due to the co-existence of multiple species. The additive...