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Minghua Fan

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Articles 18
Citations 317
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Recent Articles
1.
Eddings C, Fan M, Imoto Y, Itoh K, McDonald X, Eilers J, et al.
bioRxiv . 2025 Jan; PMID: 39763840
Live human brain tissues provide unique opportunities for understanding the physiology and pathophysiology of synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization-while crucial parameters such as...
2.
Liu Y, Fan M, Yang J, Mihaljevic L, Chen K, Ye Y, et al.
Sci Adv . 2024 May; 10(20):eadm9326. PMID: 38758792
Intellectual disability (ID) affects ~2% of the population and ID-associated genes are enriched for epigenetic factors, including those encoding the largest family of histone lysine acetyltransferases (KAT5-KAT8). Among them is...
3.
Liu J, Liao H, Fan M, Zhou T, Peng S
Ecol Evol . 2023 Jun; 13(6):e10153. PMID: 37293124
Moso-bamboo (), with the favor of human disturbance, rapidly invades adjacent forests to form monocultures in East Asia. Moso-bamboo not only intrudes the broadleaf forests but also the coniferous, and...
4.
Fan M, Dong L, Meng Y, Wang Y, Zhen J, Qiu J
Dis Markers . 2022 Dec; 2022:7052176. PMID: 36457544
The process of placental invasion is essential for a successful pregnancy. Leptin is involved in trophoblast invasiveness, and its dysregulation is connected with a series of diseases, including preeclampsia. However,...
5.
Fan M, Liu Y, Shang Y, Xue Y, Liang J, Huang Z
Biol Psychiatry . 2022 Aug; 92(10):800-814. PMID: 36008159
Background: Impairment of synaptic plasticity is closely correlated with a range of pathological conditions, such as cognitive deficits. However, how synaptic efficacy is regulated remains incompletely understood. Here, we report...
6.
Hu M, Wang Y, Meng Y, Hu J, Qiao J, Zhen J, et al.
J Cell Mol Med . 2022 Jun; 26(14):4087-4100. PMID: 35729773
Inadequate trophoblastic invasion is considered as one of hallmarks of preeclampsia (PE), which is characterized by newly onset of hypertension (>140/90 mmHg) and proteinuria (>300 mg in a 24-h urine)...
7.
Li Z, Cai G, Fang F, Li W, Fan M, Lian J, et al.
J Med Chem . 2021 May; 64(9):5551-5576. PMID: 33934604
-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated Na and Ca-permeable ion channels involved in excitatory synaptic transmission and synaptic plasticity. NMDAR hypofunction has long been implicated in the pathophysiology including major depressive...
8.
Liu B, Qiao J, Hu J, Fan M, Zhao Y, Su H, et al.
Mol Cell Biochem . 2020 Jul; 473(1-2):155-166. PMID: 32632610
Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing...
9.
Fan M, Li X, Gao X, Dong L, Xin G, Chen L, et al.
Front Physiol . 2019 Sep; 10:1030. PMID: 31507429
Accumulating evidence has shown that preeclampsia (PE) was associated with an aberrant maternal-fetal inflammatory response. In the present study, we first found that in human PE placentas levels of toll-like...
10.
Yang L, Liu Y, Fan M, Zhu G, Jin H, Liang J, et al.
Eur J Med Chem . 2019 Sep; 182:111656. PMID: 31494467
Chemical probes of epigenetic 'readers' of histone post-translational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in physiology and pathology. However, only limited...