Min Hyeon Shin
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Explore the profile of Min Hyeon Shin including associated specialties, affiliations and a list of published articles.
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7
Citations
53
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Recent Articles
1.
Lee K, Wang H, Kim M, Park J, Kim J, Jang S, et al.
J Am Chem Soc
. 2025 Feb;
PMID: 40011448
DNA-encoded library (DEL) technology is a powerful tool for discovering potent ligands for biological targets but constrained by limitations, including the insolubility of DNA in organic solvents and its instability...
2.
Lee K, Bang G, Kim Y, Shin M, Lim H
Bioorg Med Chem
. 2021 Sep;
48:116423.
PMID: 34583129
Here we describe the design and synthesis of a DNA-encoded library of bicyclic peptoids. We show that our solid-phase strategy is facile and DNA-compatible, yielding a structurally diverse combinatorial library...
3.
Kim H, Lee Y, Shin M, Lim H
Chem Commun (Camb)
. 2021 Jul;
57(55):6800-6803.
PMID: 34236370
Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of...
4.
Choi S, Wang H, Shin M, Lim H
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34203850
Steroid receptor coactivator-1 (SRC-1) is a transcription coactivator playing a pivotal role in mediating a wide range of signaling pathways by interacting with related transcription factors and nuclear receptors. Aberrantly...
5.
Lee Y, Heo J, Jeong H, Hong K, Kwon D, Shin M, et al.
Angew Chem Int Ed Engl
. 2020 Oct;
59(40):17548-17555.
PMID: 33026161
Aberrantly elevated steroid receptor coactivator-1 (SRC-1) expression and activity are strongly correlated with cancer progression and metastasis. Here we report, for the first time, the development of a proteolysis targeting...
6.
Shin M, Lee K, Lim H
Bioconjug Chem
. 2019 Oct;
30(11):2931-2938.
PMID: 31663722
We report the design and synthesis of a DNA-encoded one-bead one-compound library of cyclic peptoids composed of more than 11 million molecules. We show that affinity-based screening of this large...
7.
Shin M, Lim H
Mol Biosyst
. 2017 Mar;
13(4):638-647.
PMID: 28265599
Protein folding is crucial for most proteins to achieve their correct three-dimensional conformations and function properly. Defects in protein folding frequently caused by mutations lead to a range of protein...
8.
Lee J, Shin M, Mobley W, Urbach A, Kim H
J Am Chem Soc
. 2015 Nov;
137(48):15322-9.
PMID: 26565603
Mass spectrometry (MS)-based analysis using enzymatic digestion is widely used for protein sequencing and characterization. The large number of peptides generated from proteolysis, however, suppresses the signal of peptides with...