Miklos Sahin-Toth
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Explore the profile of Miklos Sahin-Toth including associated specialties, affiliations and a list of published articles.
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152
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3110
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Recent Articles
11.
Martonosi A, Nemeth B, Parniczky A, Vincze A, Szentesi A, Eross B, et al.
Pancreas
. 2023 Oct;
52(4):e256-e257.
PMID: 37801657
No abstract available.
12.
Nemeth B, Nagy Z, Kiss B, Gellen G, Schlosser G, Demcsak A, et al.
Pancreatology
. 2023 Aug;
23(6):742-749.
PMID: 37604733
Chymotrypsin-like protease (CTRL) is one of the four chymotrypsin isoforms expressed in the human exocrine pancreas. Human genetic and experimental evidence indicate that chymotrypsins B1, B2, and C (CTRB1, CTRB2...
13.
Berke G, Beer S, Gede N, Takats A, Szentesi A, Hegyi P, et al.
Pancreatology
. 2023 Jun;
23(5):481-490.
PMID: 37321941
Chymotrypsin C (CTRC) is a digestive serine protease produced by the pancreas that regulates intrapancreatic trypsin activity and provides a defensive mechanism against chronic pancreatitis (CP). CTRC exerts its protective...
14.
Jancso Z, Morales Granda N, Demcsak A, Sahin-Toth M
Pancreatology
. 2023 Feb;
23(2):131-142.
PMID: 36797199
Mutation p.R122H in human cationic trypsinogen (PRSS1) is the most frequently identified cause of hereditary pancreatitis. The mutation blocks protective degradation of trypsinogen by chymotrypsin C (CTRC), which involves an...
15.
Geisz A, Tran T, Orekhova A, Sahin-Toth M
Gastroenterology
. 2023 Jan;
164(4):684-687.e4.
PMID: 36641042
No abstract available.
16.
Sandor M, Thiel F, Schmid M, Demcsak A, Morales Granda N, Nemeth B, et al.
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555104
Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be associated with hereditary and idiopathic chronic pancreatitis (CP). Pathogenic mutations, such as p.N256K, cause intracellular retention and reduced...
17.
Berke G, Gede N, Szadai L, Ocskay K, Hegyi P, Sahin-Toth M, et al.
PLoS One
. 2022 Oct;
17(10):e0276397.
PMID: 36264955
Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations...
18.
Pesei Z, Jancso Z, Demcsak A, Nemeth B, Vajda S, Sahin-Toth M
JCI Insight
. 2022 Sep;
7(21).
PMID: 36136430
Pancreatitis, the inflammatory disorder of the pancreas, has no specific therapy. Genetic, biochemical, and animal model studies revealed that trypsin plays a central role in the onset and progression of...
19.
Nemeth B, Demcsak A, Micsonai A, Kiss B, Schlosser G, Geisz A, et al.
Biochim Biophys Acta Proteins Proteom
. 2022 Aug;
1870(9):140831.
PMID: 35934298
Pancreatic chymotrypsins (CTRs) are digestive proteases that in humans include CTRB1, CTRB2, CTRC, and CTRL. The highly similar CTRB1 and CTRB2 are the products of gene duplication. A common inversion...
20.
Sahin-Toth M
Pancreas
. 2022 Jul;
51(4):297-301.
PMID: 35775637
The identification of the genetic basis of hereditary pancreatitis in 1996 confirmed the critical role of trypsinogen in this disease and opened a new avenue of research on pancreatitis-associated genetic...