Mikkel Heide Schierup
Overview
Explore the profile of Mikkel Heide Schierup including associated specialties, affiliations and a list of published articles.
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49
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1240
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Recent Articles
11.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
Science
. 2023 Jun;
380(6648):eabn8153.
PMID: 37262156
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants,...
12.
Gao H, Hamp T, Ede J, Schraiber J, McRae J, Singer-Berk M, et al.
bioRxiv
. 2023 May;
PMID: 37205491
One Sentence Summary: Deep learning classifier trained on 4.3 million common primate missense variants predicts variant pathogenicity in humans.
13.
Skov L, Macia M, Lucotte E, Cavassim M, Castellano D, Schierup M, et al.
Cell Genom
. 2023 Mar;
3(3):100274.
PMID: 36950386
The X chromosome in non-African humans shows less diversity and less Neanderthal introgression than expected from neutral evolution. Analyzing 162 human male X chromosomes worldwide, we identified fourteen chromosomal regions...
14.
Murat F, Mbengue N, Boeg Winge S, Trefzer T, Leushkin E, Sepp M, et al.
Nature
. 2022 Dec;
613(7943):308-316.
PMID: 36544022
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals, probably owing to the evolutionary pressure on males to be reproductively successful....
15.
Bergman J, Schierup M
Genome Biol
. 2022 Oct;
23(1):215.
PMID: 36253794
Background: The pseudoautosomal region 1 (PAR1) is a 2.7 Mb telomeric region of human sex chromosomes. PAR1 has a crucial role in ensuring proper segregation of sex chromosomes during male...
16.
Feng S, Bai M, Rivas-Gonzalez I, Li C, Liu S, Tong Y, et al.
Cell
. 2022 Apr;
185(10):1646-1660.e18.
PMID: 35447073
Incomplete lineage sorting (ILS) makes ancestral genetic polymorphisms persist during rapid speciation events, inducing incongruences between gene trees and species trees. ILS has complicated phylogenetic inference in many lineages, including...
17.
Macia M, Skov L, Peter B, Schierup M
Nat Commun
. 2021 Sep;
12(1):5317.
PMID: 34493715
After the main Out-of-Africa event, humans interbred with Neanderthals leaving 1-2% of Neanderthal DNA scattered in small fragments in all non-African genomes today. Here we investigate what can be learned...
18.
Cavassim M, Andersen S, Bataillon T, Schierup M
Mol Biol Evol
. 2021 Aug;
38(12):5480-5490.
PMID: 34410427
Homologous recombination is expected to increase natural selection efficacy by decoupling the fate of beneficial and deleterious mutations and by readily creating new combinations of beneficial alleles. Here, we investigate...
19.
Bergman J, Schierup M
Genetics
. 2021 Jun;
218(3).
PMID: 34081117
The nucleotide composition of the genome is a balance between the origin and fixation rates of different mutations. For example, it is well-known that transitions occur more frequently than transversions,...
20.
Yang C, Zhou Y, Marcus S, Formenti G, Bergeron L, Song Z, et al.
Nature
. 2021 Apr;
594(7862):227-233.
PMID: 33910227
The accurate and complete assembly of both haplotype sequences of a diploid organism is essential to understanding the role of variation in genome functions, phenotypes and diseases. Here, using a...