Mikhail V Gorshkov
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Explore the profile of Mikhail V Gorshkov including associated specialties, affiliations and a list of published articles.
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77
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Recent Articles
1.
Ivanov M, Kopeykina A, Kazakova E, Tarasova I, Sun Z, Postoenko V, et al.
J Proteome Res
. 2025 Feb;
24(3):1053-1066.
PMID: 39984290
Many factors negatively affect a generalization of the findings in discovery proteomics. They include differentiation between patient cohorts, a variety of experimental conditions, etc. We presented a machine-learning-based workflow for...
2.
Fedorov I, Ivanov M, Gorshkov M
Anal Chem
. 2024 Dec;
97(1):22-26.
PMID: 39720990
In this Letter, a two-term formalism for constructing protein solubility curves in thermal proteome profiling (TPP) is considered, which takes into account the efficiency of the drug-protein binding reaction. When...
3.
Fedorov I, Protasov S, Tarasova I, Gorshkov M
Biochemistry (Mosc)
. 2024 Sep;
89(8):1349-1361.
PMID: 39245450
Current stage of proteomic research in the field of biology, medicine, development of new drugs, population screening, or personalized approaches to therapy dictates the need to analyze large sets of...
4.
Ivanov M, Kopeykina A, Gorshkov M
J Am Soc Mass Spectrom
. 2024 Jun;
35(8):1775-1785.
PMID: 38938158
Data-independent acquisition (DIA) at the shortened data acquisition time is becoming a method of choice for quantitative proteomic applications requiring high throughput analysis of large cohorts of samples. With the...
5.
Fedorov I, Bubis J, Kazakova E, Lobas A, Ivanov M, Emekeeva D, et al.
Anal Bioanal Chem
. 2024 May;
416(18):4083-4089.
PMID: 38744720
Advances in high-throughput high-resolution mass spectrometry and the development of thermal proteome profiling approach (TPP) have made it possible to accelerate a drug target search. Since its introduction in 2014,...
6.
Lobas A, Saei A, Lyu H, Zubarev R, Gorshkov M
ACS Pharmacol Transl Sci
. 2024 Mar;
7(3):787-796.
PMID: 38481686
Rapamycin is a natural antifungal, immunosuppressive, and antiproliferative compound that allosterically inhibits mTOR complex 1. The ubiquitin-proteasome system (UPS) responsible for protein turnover is usually not listed among the pathways...
7.
Postoenko V, Garibova L, Levitsky L, Bubis J, Gorshkov M, Ivanov M
J Proteome Res
. 2023 Aug;
22(9):2827-2835.
PMID: 37579078
One of the key steps in data dependent acquisition (DDA) proteomics is detection of peptide isotopic clusters, also called "features", in MS1 spectra and matching them to MS/MS-based peptide identifications....
8.
Ivanov M, Garibova L, Postoenko V, Levitsky L, Gorshkov M
Proteomics
. 2023 Jul;
24(1-2):e2300090.
PMID: 37496303
The coefficient of variation (CV) is often used in proteomics as a proxy to characterize the performance of a quantitation method and/or the related software. In this note, we question...
9.
Penanes P, Gorshkov V, Ivanov M, Gorshkov M, Kjeldsen F
J Proteome Res
. 2023 Jul;
22(8):2734-2742.
PMID: 37395192
Current proteomics approaches rely almost exclusively on using the positive ionization mode, resulting in inefficient ionization of many acidic peptides. This study investigates protein identification efficiency in the negative ionization...
10.
Levitsky L, Ivanov M, Goncharov A, Kliuchnikova A, Bubis J, Lobas A, et al.
J Proteome Res
. 2023 May;
22(6):1695-1711.
PMID: 37158322
The proteogenomic search pipeline developed in this work has been applied for reanalysis of 40 publicly available shotgun proteomic datasets from various human tissues comprising more than 8000 individual LC-MS/MS...