Mike Dragunow
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Explore the profile of Mike Dragunow including associated specialties, affiliations and a list of published articles.
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108
Citations
3796
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Recent Articles
1.
Tan A, Martinez L, Murray H, Mehrabi N, Tippett L, Turner C, et al.
Neurobiol Dis
. 2025 Feb;
206:106829.
PMID: 39909082
Although the genetic basis of Huntington's disease (HD) has been determined, the underlying pathophysiological mechanisms contributing to neurodegeneration remain largely unknown. In recent years, increasing evidence has posited vascular dysfunction...
2.
Vong C, Wang A, Dragunow M, Park T, Shim V
Comput Biol Med
. 2025 Jan;
186:109642.
PMID: 39787663
Problem: Machine learning (ML)/Deep learning (DL) techniques have been evolving to solve more complex diseases, but it has been used relatively little in Glioblastoma (GBM) histopathological studies, which could benefit...
3.
Carmichael-Lowe A, Fleming B, Reddy K, Wiseman J, Yin E, Turner C, et al.
PLoS One
. 2024 Dec;
19(12):e0315183.
PMID: 39689145
Antigen retrieval is crucial for immunohistochemistry, particularly in formalin-fixed paraffin-embedded brain tissue, where fixation causes extensive crosslinking that masks epitopes. Heat Induced Epitope Retrieval (HIER) reverses these crosslinks, improving access...
4.
Liu H, Tan A, Mehrabi N, Turner C, Curtis M, Faull R, et al.
Neurobiol Dis
. 2024 Nov;
204():106749.
PMID: 39603277
Alzheimer's disease (AD) has complex pathophysiology involving numerous cell types and brain processes. Astrocyte involvement in AD is gaining increased attention, however a complete characterisation of astrocytic changes in the...
5.
Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex
Tan A, Tippett L, Turner C, Swanson M, Park T, Curtis M, et al.
Neurobiol Dis
. 2024 Jun;
198:106554.
PMID: 38844243
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both contribute to basal ganglia pathology, the...
6.
Cooper E, Oyagawa C, Johnson R, Choi P, Foliaki J, Correia J, et al.
Cell Commun Signal
. 2024 Jan;
22(1):30.
PMID: 38212807
Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the...
7.
Cao M, Ryan B, Wu J, Curtis M, Faull R, Dragunow M, et al.
Neurobiol Dis
. 2023 Aug;
185:106245.
PMID: 37527763
TDP-43 dysfunction is a molecular hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A major hypothesis of TDP-43 dysfunction in disease is the loss of normal nuclear function,...
8.
Vong C, Wang A, Dragunow M, Park T, Shim V
Cytometry A
. 2023 Feb;
103(6):518-527.
PMID: 36786336
Current analysis techniques available for migration assays only provide quantitative measurements for overall migration. However, the potential of regional migration analyses can open further insight into migration patterns and more...
9.
Highet B, Wiseman J, Mein H, Parker R, Ryan B, Turner C, et al.
J Alzheimers Dis
. 2023 Feb;
92(1):371-390.
PMID: 36744342
Background: Alzheimer's disease (AD) is the most common form of dementia and is characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated that neurons involved in memory function...
10.
Wu Y, Park T, Kwon E, Feng S, Schweder P, Dragunow M, et al.
Front Neurosci
. 2022 Nov;
16:994251.
PMID: 36440264
Traumatic brain injury (TBI) is defined as brain damage due to an external force that negatively impacts brain function. Up to 90% of all TBI are considered in the mild...